Document Detail


Neurochemistry of bulbospinal presympathetic neurons of the medulla oblongata.
MedLine Citation:
PMID:  19665549     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This review focuses on presympathetic neurons in the medulla oblongata including the adrenergic cell groups C1-C3 in the rostral ventrolateral medulla and the serotonergic, GABAergic and glycinergic neurons in the ventromedial medulla. The phenotypes of these neurons including colocalized neuropeptides (e.g., neuropeptide Y, enkephalin, thyrotropin-releasing hormone, substance P) as well as their relative anatomical location are considered in relation to predicting their function in control of sympathetic outflow, in particular the sympathetic outflows controlling blood pressure and thermoregulation. Several explanations are considered for how the neuroeffectors coexisting in these neurons might be functioning, although their exact purpose remains unknown. Although there is abundant data on potential neurotransmitters and neuropeptides contained in the presympathetic neurons, we are still unable to predict function and physiology based solely on the phenotype of these neurons.
Authors:
Ruth L Stornetta
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2009-08-07
Journal Detail:
Title:  Journal of chemical neuroanatomy     Volume:  38     ISSN:  1873-6300     ISO Abbreviation:  J. Chem. Neuroanat.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-09-25     Completed Date:  2009-12-15     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  8902615     Medline TA:  J Chem Neuroanat     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  222-30     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Autonomic Pathways / chemistry*,  cytology,  physiology
Body Temperature Regulation / physiology
Cardiovascular Physiological Phenomena*
Humans
Medulla Oblongata / chemistry*,  cytology,  physiology
Neurons / chemistry
Neurotransmitter Agents / physiology*
Reticular Formation / chemistry,  cytology,  physiology
Sympathetic Nervous System / chemistry*,  cytology,  physiology
Grant Support
ID/Acronym/Agency:
HL28785/HL/NHLBI NIH HHS; HL74011/HL/NHLBI NIH HHS; R01 HL028785/HL/NHLBI NIH HHS; R01 HL028785-28/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Neurotransmitter Agents
Comments/Corrections

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