| Neurochemical correlates of sexual exhaustion and recovery as assessed by in vivo microdialysis. | |
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MedLine Citation:
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PMID: 7540927 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The extracellular levels of the dopamine (DA) metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) and the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the medial preoptic area (MPOA) of male rats were monitored during unrestricted copulation, the ensuing state of sexual refractoriness and the resumption of mating activity. MPOA dialysates were collected from the same animal during four consecutive days. In the first day the subjects were allowed to copulate until reaching a satiation criterion. That was associated with a marked increase in the dialysate levels of the three metabolites assessed. During the next two days the animals remained sexually inactive when exposed to receptive females. Their basal levels of DOPAC and HVA were elevated, whereas those of 5-HIAA remained as low as in the first session. During the non-mating exposure to receptive females there were only minor changes in the three metabolites. By the fourth day, just before the animals resumed copulation, the basal levels of the DA metabolites, especially HVA, had decreased to values closer to those found in the first day. When they mated again to exhaustion the levels of DOPAC, HVA, and 5-HIAA increased as in the first session. The neurochemical changes found during the intervening state of sexual inactivity (i.e. increased levels of DA metabolites) are reminiscent of the effects of DA receptor blockers, which suggests a possible neurochemical mechanism for sexual refractoriness. |
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Authors:
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M Mas; B Fumero; J R Fernandez-Vera; J L Gonzalez-Mora |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research Volume: 675 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1995 Mar |
Date Detail:
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Created Date: 1995-08-03 Completed Date: 1995-08-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 13-9 Citation Subset: IM |
Affiliation:
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Department of Physiology, University of La Laguna, Medical School, Tenerife, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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3,4-Dihydroxyphenylacetic Acid
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metabolism Animals Brain Chemistry / physiology* Chromatography, High Pressure Liquid Copulation / physiology Dopamine / metabolism Ejaculation / physiology Extracellular Space / metabolism Homovanillic Acid / metabolism Hydroxyindoleacetic Acid / metabolism Male Microdialysis Preoptic Area / metabolism Rats Rats, Sprague-Dawley Satiety Response / physiology* Serotonin / metabolism Sexual Behavior, Animal / physiology* |
| Chemical | |
Reg. No./Substance:
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102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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