Document Detail

Neurochemical correlates of sexual exhaustion and recovery as assessed by in vivo microdialysis.
MedLine Citation:
PMID:  7540927     Owner:  NLM     Status:  MEDLINE    
The extracellular levels of the dopamine (DA) metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) and the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the medial preoptic area (MPOA) of male rats were monitored during unrestricted copulation, the ensuing state of sexual refractoriness and the resumption of mating activity. MPOA dialysates were collected from the same animal during four consecutive days. In the first day the subjects were allowed to copulate until reaching a satiation criterion. That was associated with a marked increase in the dialysate levels of the three metabolites assessed. During the next two days the animals remained sexually inactive when exposed to receptive females. Their basal levels of DOPAC and HVA were elevated, whereas those of 5-HIAA remained as low as in the first session. During the non-mating exposure to receptive females there were only minor changes in the three metabolites. By the fourth day, just before the animals resumed copulation, the basal levels of the DA metabolites, especially HVA, had decreased to values closer to those found in the first day. When they mated again to exhaustion the levels of DOPAC, HVA, and 5-HIAA increased as in the first session. The neurochemical changes found during the intervening state of sexual inactivity (i.e. increased levels of DA metabolites) are reminiscent of the effects of DA receptor blockers, which suggests a possible neurochemical mechanism for sexual refractoriness.
M Mas; B Fumero; J R Fernandez-Vera; J L Gonzalez-Mora
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain research     Volume:  675     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1995 Mar 
Date Detail:
Created Date:  1995-08-03     Completed Date:  1995-08-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  13-9     Citation Subset:  IM    
Department of Physiology, University of La Laguna, Medical School, Tenerife, Spain.
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MeSH Terms
3,4-Dihydroxyphenylacetic Acid / metabolism
Brain Chemistry / physiology*
Chromatography, High Pressure Liquid
Copulation / physiology
Dopamine / metabolism
Ejaculation / physiology
Extracellular Space / metabolism
Homovanillic Acid / metabolism
Hydroxyindoleacetic Acid / metabolism
Preoptic Area / metabolism
Rats, Sprague-Dawley
Satiety Response / physiology*
Serotonin / metabolism
Sexual Behavior, Animal / physiology*
Reg. No./Substance:
102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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