Document Detail

Neurochemical abnormalities in brains of renal failure patients treated by repeated hemodialysis.
MedLine Citation:
PMID:  2411864     Owner:  NLM     Status:  MEDLINE    
We examined autopsied brain from 10 patients with end-stage renal failure who had undergone repeated hemodialysis. Eight had classic symptoms, and two had suggestive symptoms of dialysis encephalopathy. Findings were compared with those in autopsied brain from control adults who had never been hemodialyzed. Mean gamma-aminobutyric acid (GABA) contents were significantly reduced in frontal and occipital cortex, cerebellar cortex, dentate nucleus, caudate nucleus, and medial-dorsal thalamus of the hemodialyzed patients, the reduction being greater than 40% in cerebral cortex and thalamus. Choline acetyltransferase activity was reduced by 25-35% in three cortical regions in the hemodialyzed patients. These two abnormalities were observed in the brain of each hemodialyzed patient, regardless of whether or not the patient died with unequivocal dialysis encephalopathy. Pyridoxal phosphate contents were substantially reduced in brains of the hemodialyzed patients, but metabolites of noradrenaline, 3,4-dihydroxyphenylethylamine (dopamine), and 5-hydroxytryptamine (serotonin) were present in normal amounts. Aluminum levels were abnormally high in frontal cortical gray matter in the hemodialyzed patients. Although this study does not clarify the role played by aluminum toxicity in the pathogenesis of dialysis encephalopathy, the abnormalities we found suggest the need for further neurochemical investigations in this disorder.
T L Perry; V W Yong; S J Kish; M Ito; J G Foulks; W J Godolphin; V P Sweeney
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  45     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  1985 Oct 
Date Detail:
Created Date:  1985-10-11     Completed Date:  1985-10-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1043-8     Citation Subset:  IM    
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MeSH Terms
Aluminum / analysis
Amino Acids / analysis
Brain / pathology*
Brain Chemistry*
Choline O-Acetyltransferase / metabolism
Homovanillic Acid / analysis
Hydroxyindoleacetic Acid / analysis
Kidney Failure, Chronic / pathology*,  therapy
Methoxyhydroxyphenylglycol / analysis
Pyridoxal Phosphate / analysis
Renal Dialysis*
Tissue Distribution
gamma-Aminobutyric Acid / analysis
Reg. No./Substance:
0/Amino Acids; 306-08-1/Homovanillic Acid; 534-82-7/Methoxyhydroxyphenylglycol; 54-16-0/Hydroxyindoleacetic Acid; 54-47-7/Pyridoxal Phosphate; 56-12-2/gamma-Aminobutyric Acid; 7429-90-5/Aluminum; EC O-Acetyltransferase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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