| Neurochemical oscillations in the basal ganglia. | |
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MedLine Citation:
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PMID: 19588207 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This work represents an attempt to elucidate the neurochemical processes in the basal ganglia by mathematical modelling. The correlation between neurochemistry and electrophysiology has been used to construct a dynamical system based on the basal ganglia's network structure. Mathematical models were constructed for different physical scales to reformulate the neurochemical and electrophysiological behaviour from synapses up to multi-compartment systems. Transformation functions have been developed to transit between the different scales. We show through numerical simulations that this network produces oscillations in the electrical potentials as well as in neurotransmitter concentrations. In agreement with pharmacological experiments, a parameter sensitivity analysis reveals temporary changes in the neurochemical and electrophysiological systems after single exposure to antipsychotic drugs. This behaviour states the structural stability of the system. The correlation between the neurochemical dynamics and drug-induced behaviour provides the perspective for novel neurobiological hypotheses. |
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Authors:
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Hamid Reza Noori; Willi J?ger |
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Publication Detail:
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Type: Journal Article Date: 2009-07-09 |
Journal Detail:
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Title: Bulletin of mathematical biology Volume: 72 ISSN: 1522-9602 ISO Abbreviation: Bull. Math. Biol. Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2010-01-11 Completed Date: 2010-03-12 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401404 Medline TA: Bull Math Biol Country: United States |
Other Details:
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Languages: eng Pagination: 133-47 Citation Subset: IM |
Affiliation:
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Interdisciplinary Center for Scientific Computing, University of Heidelberg, 69120 Heidelberg, Germany. hamid.reza.noori@iwr.uni-heidelberg.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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physiology Basal Ganglia / physiology* Biological Clocks / physiology* Computer Simulation Humans Neural Networks (Computer)* Neurotransmitter Agents / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Neurotransmitter Agents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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