Document Detail


Neurochemical and neurostructural plasticity in alcoholism.
MedLine Citation:
PMID:  22896799     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The behavioral manifestations of alcoholism are primarily attributable to the numerous and lasting adaptations that occur in the brain as a result of chronic heavy alcohol consumption. As will be reviewed here, these adaptations include alcohol-induced plasticity in chemical neurotransmission, density and morphology of dendritic spines, as well as neurodegeneration and cerebral atrophy. Within the context of these neuroadaptations that have been observed in both human and animal studies, we will discuss how these changes potentially contribute to the cognitive and behavioral dysfunctions that are hallmark features of alcoholism, as well as how they reveal novel potential pharmacological targets for the treatment of this disorder.
Authors:
Justin T Gass; M Foster Olive
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2012-04-16
Journal Detail:
Title:  ACS chemical neuroscience     Volume:  3     ISSN:  1948-7193     ISO Abbreviation:  ACS Chem Neurosci     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-08-16     Completed Date:  2013-08-20     Revised Date:  2014-07-04    
Medline Journal Info:
Nlm Unique ID:  101525337     Medline TA:  ACS Chem Neurosci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  494-504     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological / physiology*
Alcohol Drinking / metabolism,  pathology,  psychology
Alcoholism / metabolism*,  pathology,  psychology
Animals
Brain / metabolism*,  pathology
Brain Chemistry / physiology*
Dendritic Spines / chemistry,  metabolism,  pathology
Humans
Neuronal Plasticity / physiology*
Grant Support
ID/Acronym/Agency:
K99AA020537/AA/NIAAA NIH HHS; R00 AA020537/AA/NIAAA NIH HHS; R01 AA013852/AA/NIAAA NIH HHS; R01AA013852/AA/NIAAA NIH HHS
Comments/Corrections

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