| Neuroblasts: a model for the asymmetric division of stem cells. | |
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MedLine Citation:
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PMID: 9009846 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ability of stem cells to self-renew has hung been attributed to an asymmetry in division that generates one daughter cell identical to the mother and another cell committed to differentiation. Recent studies on neuroblasts, a group of neural stem cells responsible for generating various neurons and glial cells in the central nervous system, have revealed exciting mechanisms that underlie self-renewing asymmetric division. Several important localized cell fate determinants have been characterized, and their segregation mechanism has been explored in the context of cytoskeletal organization, cell-cycle type progression, cytokinesis and mitotic orientation. These findings are illuminating in understanding the general mechanism of stem cell division. |
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Authors:
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H Lin; T Schagat |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Trends in genetics : TIG Volume: 13 ISSN: 0168-9525 ISO Abbreviation: Trends Genet. Publication Date: 1997 Jan |
Date Detail:
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Created Date: 1997-02-27 Completed Date: 1997-02-27 Revised Date: 2008-10-16 |
Medline Journal Info:
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Nlm Unique ID: 8507085 Medline TA: Trends Genet Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 33-9 Citation Subset: IM |
Affiliation:
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Department of Cell Biology, Duke University Medical School, Durham, NC 27710, USA. halfan_lin@cellbio.duke.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Differentiation Cell Division Drosophila / embryology, physiology Drosophila Proteins* Gene Expression Regulation, Developmental Juvenile Hormones / physiology Mammals / physiology Membrane Proteins / physiology Models, Biological Nerve Tissue Proteins / physiology Neurons / cytology*, physiology* Nuclear Proteins / physiology Receptors, Notch Signal Transduction Stem Cells / cytology, physiology* Transcription Factors* |
| Grant Support | |
ID/Acronym/Agency:
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R01HD33760-01/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Drosophila Proteins; 0/Juvenile Hormones; 0/Membrane Proteins; 0/Nerve Tissue Proteins; 0/Nuclear Proteins; 0/Receptors, Notch; 0/Transcription Factors; 0/notch protein, Drosophila; 0/numb protein, Drosophila; 0/pros protein, Drosophila |
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