Document Detail

Neuroblastoma of the elderly, an oncologist's nightmare: case presentation, literature review and SEER database analysis.
MedLine Citation:
PMID:  25071978     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Neuroblastoma is considered a pediatric malignancy as over 95% of cases are diagnosed in patients ≤10 years old. This cancer is extremely rare in elderly patients. We conducted a Surveillance, Epidemiology, and End Results (SEER) database analysis in the USA between 1973-2007 that revealed only 35 elderly patients (>60 years of age) with neuroblastoma of whom only 2 patients had primary mediastinal neuroblastoma. There is a paucity of treatment and survival outcomes data for the elderly owing to the rarity of neuroblastoma in this population. Currently there are no standard guidelines or protocols for treatment of adult neuroblastoma. We report a rare and challenging case of an 86-year old patient presenting with mediastinal neuroblastoma and syndrome of inappropriate antidiuretic hormone secretion (SIADH) successfully treated with resection. Herein, we also provide a review of the literature and updated survival data on neuroblastoma based on results of our SEER database review.
Elisa Rogowitz; Hani M Babiker; Mohammed Kanaan; Rebecca A Millius; Q Scott Ringenberg; Maria Bishop
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Publication Detail:
Type:  Journal Article     Date:  2014-07-17
Journal Detail:
Title:  Experimental hematology & oncology     Volume:  3     ISSN:  2162-3619     ISO Abbreviation:  Exp Hematol Oncol     Publication Date:  2014  
Date Detail:
Created Date:  2014-07-29     Completed Date:  2014-07-29     Revised Date:  2014-07-31    
Medline Journal Info:
Nlm Unique ID:  101590676     Medline TA:  Exp Hematol Oncol     Country:  England    
Other Details:
Languages:  eng     Pagination:  20     Citation Subset:  -    
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