Document Detail


Neuroblastoma and adrenal morphologic features in anencephalic infants.
MedLine Citation:
PMID:  581837     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
At autopsy, an incidental congenital neuroblastoma was found in the adrenal gland of an 8-day-old full-term anencephalic baby. This previously unreported coincidence of neuroblastoma and anencephaly prompted a retrospective study of adrenal morphologic features in 20 anencephalic patients and 20 matched controls. Anencephalic adrenal glands were smaller and the fasciculoreticular zone was thinner (average 32%) than in the normal controls (average 76%). The neural crest-derived cells represented an average of 2% of the total gland area in anencephalic patients and 0.5% in the controls. These findings, statistically significant and compatible with previous studies, verify the deficient development of the fetal cortex in anencephalic patients. Furthermore, the neural component in anencephalic patients may be delayed in its maturation by the abnormal cortex, and thus may be prone to undergo malignant transformation and become a neuroblastoma.
Authors:
H M Van Hale; S B Turkel
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of pathology & laboratory medicine     Volume:  103     ISSN:  0003-9985     ISO Abbreviation:  Arch. Pathol. Lab. Med.     Publication Date:  1979 Mar 
Date Detail:
Created Date:  1979-05-23     Completed Date:  1979-05-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7607091     Medline TA:  Arch Pathol Lab Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  119-21     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adrenal Cortex / pathology
Adrenal Gland Neoplasms / complications*,  pathology
Adrenal Medulla / pathology
Anencephaly / complications*,  pathology
Female
Humans
Infant, Newborn
Male
Neural Crest / pathology
Neuroblastoma / complications*,  pathology
Retrospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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