Document Detail

Neurobiology of self-awareness in schizophrenia: an fMRI study.
MedLine Citation:
PMID:  22480958     Owner:  NLM     Status:  MEDLINE    
Self-awareness (SA) is one of the core domains of higher cortical functions and is frequently compromised in schizophrenia. Deficits in SA have been associated with functional and psychosocial impairment in this patient population. However, despite its clinical significance, only a few studies have examined the neural substrates of self-referential processing in schizophrenia. The aim of this study was to assess self-awareness in schizophrenia using a functional magnetic resonance imaging (fMRI) paradigm designed to elicit judgments of self-reference in a simulated social context. While scanned, volunteers looked at visually-displayed sentences that had the volunteer's own first name (self-directed sentence-stimulus) or an unknown other person's first name (other-directed sentence stimulus) as the grammatical subject of the sentence. The volunteers were asked to discern whether each sentence-stimulus was about the volunteer personally (during a self-referential cue epoch) or asked whether each statement was about someone else (during an other-referential cue epoch). We predicted that individuals with schizophrenia would demonstrate altered functional activation to self- and other-directed sentence-stimuli as compared to controls. Fifteen controls and seventeen schizophrenia volunteers completed clinical assessments and SA fMRI task on a 3T Philips 3.0 T Achieva system. The results showed significantly greater activation in schizophrenia compared to controls for cortical midline structures in response to self- vs. other-directed sentence-stimuli. These findings support results from earlier studies and demonstrate selective alteration in the activation of cortical midline structures associated with evaluations of self-reference in schizophrenia as compared to controls.
Mujeeb U Shad; Matcheri S Keshavan; Joel L Steinberg; Perry Mihalakos; Binu P Thomas; Michael A Motes; Jair C Soares; Carol A Tamminga
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-04-04
Journal Detail:
Title:  Schizophrenia research     Volume:  138     ISSN:  1573-2509     ISO Abbreviation:  Schizophr. Res.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-11     Completed Date:  2012-10-24     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  113-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
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MeSH Terms
Case-Control Studies
Cerebral Cortex / physiopathology*
Functional Neuroimaging
Magnetic Resonance Imaging
Middle Aged
Parietal Lobe / physiopathology*
Schizophrenia / physiopathology*
Schizophrenic Psychology*
Self Concept*
Grant Support
K23 MH 077924-05/MH/NIMH NIH HHS; K23 MH077924/MH/NIMH NIH HHS; K23 MH077924-05/MH/NIMH NIH HHS; UL1 RR024148/RR/NCRR NIH HHS

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