| Neurobiology of hyperactivity and reward: agreeable restlessness in anorexia nervosa. | |
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MedLine Citation:
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PMID: 20361989 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Restricted food intake is associated with increased physical activity, very likely an evolutionary advantage, initially both functional and rewarding. The hyperactivity of patients with anorexia nervosa, however, is a main problem for recovery. This seemingly paradoxical reward of hyperactivity in anorexia nervosa is one of the main aspects in our framework for the neurobiological changes that may underlie the development of the disorder. Here, we focus on the neurobiological basis of hyperactivity and reward in both animals and humans suggesting that the mesolimbic dopamine and hypothalamic orexin neurons play central roles. The paper represents an invited review by a symposium, award winner or keynote speaker at the Society for the Study of Ingestive Behavior [SSIB] Annual Meeting in Portland, July 2009. |
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Authors:
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Anton J W Scheurink; Gretha J Boersma; Ricard Nergårdh; Per Södersten |
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Publication Detail:
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Type: Journal Article; Review Date: 2010-03-31 |
Journal Detail:
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Title: Physiology & behavior Volume: 100 ISSN: 1873-507X ISO Abbreviation: Physiol. Behav. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-15 Completed Date: 2010-09-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0151504 Medline TA: Physiol Behav Country: United States |
Other Details:
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Languages: eng Pagination: 490-5 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Neuroendocrinology, University of Groningen, The Netherlands. a.j.w.scheurink@rug.nl |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anorexia Nervosa / complications*, psychology* Dopamine / metabolism Humans Hyperkinesis / complications* Intracellular Signaling Peptides and Proteins / metabolism Neurobiology* Neuropeptides / metabolism Psychomotor Agitation / etiology* Reward* |
| Chemical | |
Reg. No./Substance:
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0/Intracellular Signaling Peptides and Proteins; 0/Neuropeptides; 0/orexins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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