Document Detail

Neurobiology of hyperactivity and reward: agreeable restlessness in anorexia nervosa.
MedLine Citation:
PMID:  20361989     Owner:  NLM     Status:  MEDLINE    
Restricted food intake is associated with increased physical activity, very likely an evolutionary advantage, initially both functional and rewarding. The hyperactivity of patients with anorexia nervosa, however, is a main problem for recovery. This seemingly paradoxical reward of hyperactivity in anorexia nervosa is one of the main aspects in our framework for the neurobiological changes that may underlie the development of the disorder. Here, we focus on the neurobiological basis of hyperactivity and reward in both animals and humans suggesting that the mesolimbic dopamine and hypothalamic orexin neurons play central roles. The paper represents an invited review by a symposium, award winner or keynote speaker at the Society for the Study of Ingestive Behavior [SSIB] Annual Meeting in Portland, July 2009.
Anton J W Scheurink; Gretha J Boersma; Ricard Nergårdh; Per Södersten
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-03-31
Journal Detail:
Title:  Physiology & behavior     Volume:  100     ISSN:  1873-507X     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-15     Completed Date:  2010-09-16     Revised Date:  2014-03-25    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  490-5     Citation Subset:  IM    
Copyright Information:
2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Anorexia Nervosa / complications*,  psychology*
Dopamine / metabolism
Hyperkinesis / complications*
Intracellular Signaling Peptides and Proteins / metabolism
Neuropeptides / metabolism
Psychomotor Agitation / etiology*
Reg. No./Substance:
0/Intracellular Signaling Peptides and Proteins; 0/Neuropeptides; 0/orexins; VTD58H1Z2X/Dopamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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