Document Detail


Neurobiology of food anticipatory circadian rhythms.
MedLine Citation:
PMID:  21527266     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Mistlberger, R.E. Neurobiology of food anticipatory circadian rhythms. Physiol Behav 00(00):000-000, 2011. Circadian rhythms in mammals can be entrained by daily schedules of light or food availability. A master light-entrainable circadian pacemaker located in the suprachiasmatic nucleus (SCN) is comprised of a population of cell autonomous, transcriptionally based circadian oscillators with defined retinal inputs, circadian clock genes and neural outputs. By contrast, the neurobiology of food-entrainable circadian rhythmicity remains poorly understood at the systems and cellular levels. Induction of food-anticipatory activity rhythms by daily feeding schedules does not require the SCN, but these rhythms do exhibit defining properties of circadian clock control. Clock gene rhythms expressed in other brain regions and in peripheral organs are preferentially reset by mealtime, but lesions of specific hypothalamic, corticolimbic and brainstem structures do not eliminate all food anticipatory rhythms, suggesting control by a distributed, decentralized system of oscillators, or the existence of a critical oscillator at an unknown location. The melanocortin system and dorsomedial hypothalamus may play modulatory roles setting the level of anticipatory activity. The metabolic hormones ghrelin and leptin are not required to induce behavioral food anticipatory rhythms, but may also participate in gain setting. Clock gene mutations that disrupt light-entrainable rhythms generally do not eliminate food anticipatory rhythms, suggesting a novel timing mechanism. Recent evidence for non-transcriptional and network based circadian rhythmicity provides precedence, but any such mechanisms are likely to interact closely with known circadian clock genes, and some important double and triple clock gene knockouts remain to be phenotyped for food entrainment. Given the dominant role of food as an entraining stimulus for metabolic rhythms, the timing of daily food intake and the fidelity of food entrainment mechanisms are likely to have clinical relevance.
Authors:
Ralph E Mistlberger
Related Documents :
23114956 - Relationship between body mass index with dietary fiber intake and skinfolds: differenc...
21365776 - The jaw adductors of strepsirrhines in relation to body size, diet, and ingested food s...
21487426 - Micronutrient recommendation stakeholders' beliefs on dietary guidelines: a qualitative...
21505736 - Capuchin monkeys are not prosocial in an instrumental helping task.
11298006 - Allergens from fish and egg.
16941156 - The right tool for the job: what strategies do wild new caledonian crows use?
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-20
Journal Detail:
Title:  Physiology & behavior     Volume:  -     ISSN:  1873-507X     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-29     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011. Published by Elsevier Inc.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  A right visual field advantage for tool-recognition in the visual half-field paradigm.
Next Document:  UVS is rare in seabirds.