Document Detail

Neurobiological plausibility of prenatal nutritional deprivation as a risk factor for schizophrenia.
MedLine Citation:
PMID:  8596115     Owner:  NLM     Status:  MEDLINE    
Emerging evidence indicates that schizophrenia may in some cases be a neurodevelopmental disorder, resulting in part from the effects of prenatal exposures. Studies by our group have focused attention on the potential role of prenatal nutritional deficiency as a potential etiological factor. Therefore, we sought to examine the biological plausibility of prenatal nutritional deprivation in the etiopathogenesis of schizophrenia. We conducted a review of the pertinent literature. Four lines of evidence support prenatal nutritional deficiencies as a plausible set of risk factors for schizophrenia: a) their effects are not incompatible with the epidemiology of schizophrenia; b) they have adverse effects on brain development; c) general malnutrition results in neuropathological anomalies of brain regions implicated in schizophrenia; and d) prenatal malnutrition affects maternal systems critical to the developing fetal nervous system. There is sufficient evidence to warrant further studies of prenatal nutritional deficits as risk factors for schizophrenia. A strategy for testing these hypotheses is outlined.
A S Brown; E S Susser; P D Butler; R Richardson Andrews; C A Kaufmann; J M Gorman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of nervous and mental disease     Volume:  184     ISSN:  0022-3018     ISO Abbreviation:  J. Nerv. Ment. Dis.     Publication Date:  1996 Feb 
Date Detail:
Created Date:  1996-04-17     Completed Date:  1996-04-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375402     Medline TA:  J Nerv Ment Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  71-85     Citation Subset:  AIM; IM    
Department of Psychiatry, Columbia University, New York, 10032, USA.
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MeSH Terms
Brain / embryology,  growth & development
Folic Acid Deficiency / complications
Infant, Newborn
Iodine / deficiency
Maternal Exposure
Nutrition Disorders / complications,  epidemiology*
Pregnancy Complications / epidemiology*
Prenatal Exposure Delayed Effects*
Risk Factors
Schizophrenia / epidemiology,  etiology*
Stress, Psychological / complications,  epidemiology
Thyroid Hormones / deficiency
Zinc / deficiency
Reg. No./Substance:
0/Thyroid Hormones; 7440-66-6/Zinc; 7553-56-2/Iodine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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