| Neurobiological plausibility of prenatal nutritional deprivation as a risk factor for schizophrenia. | |
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MedLine Citation:
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PMID: 8596115 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Emerging evidence indicates that schizophrenia may in some cases be a neurodevelopmental disorder, resulting in part from the effects of prenatal exposures. Studies by our group have focused attention on the potential role of prenatal nutritional deficiency as a potential etiological factor. Therefore, we sought to examine the biological plausibility of prenatal nutritional deprivation in the etiopathogenesis of schizophrenia. We conducted a review of the pertinent literature. Four lines of evidence support prenatal nutritional deficiencies as a plausible set of risk factors for schizophrenia: a) their effects are not incompatible with the epidemiology of schizophrenia; b) they have adverse effects on brain development; c) general malnutrition results in neuropathological anomalies of brain regions implicated in schizophrenia; and d) prenatal malnutrition affects maternal systems critical to the developing fetal nervous system. There is sufficient evidence to warrant further studies of prenatal nutritional deficits as risk factors for schizophrenia. A strategy for testing these hypotheses is outlined. |
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Authors:
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A S Brown; E S Susser; P D Butler; R Richardson Andrews; C A Kaufmann; J M Gorman |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Journal of nervous and mental disease Volume: 184 ISSN: 0022-3018 ISO Abbreviation: J. Nerv. Ment. Dis. Publication Date: 1996 Feb |
Date Detail:
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Created Date: 1996-04-17 Completed Date: 1996-04-17 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0375402 Medline TA: J Nerv Ment Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 71-85 Citation Subset: AIM; IM |
Affiliation:
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Department of Psychiatry, Columbia University, New York, 10032, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Brain
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embryology,
growth & development Female Folic Acid Deficiency / complications Humans Infant, Newborn Iodine / deficiency Maternal Exposure Nutrition Disorders / complications, epidemiology* Pregnancy Pregnancy Complications / epidemiology* Prenatal Exposure Delayed Effects* Risk Factors Schizophrenia / epidemiology, etiology* Stress, Psychological / complications, epidemiology Thyroid Hormones / deficiency Zinc / deficiency |
| Chemical | |
Reg. No./Substance:
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0/Thyroid Hormones; 7440-66-6/Zinc; 7553-56-2/Iodine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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