Document Detail


Neurobiological mechanisms of panic anxiety: biochemical and behavioral correlates of yohimbine-induced panic attacks.
MedLine Citation:
PMID:  3037926     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of yohimbine, an alpha 2-adrenergic receptor antagonist, on anxiety, blood pressure, heart rate, and plasma levels of the norepinephrine metabolite 3-methoxy-4-hydroxyphenylglycol (MHPG) and cortisol were determined in 20 healthy subjects and 68 patients who had agoraphobia with panic attacks or panic disorder. Yohimbine produced panic attacks meeting DSM-III criteria in 37 patients and one healthy subject. The patients reporting yohimbine-induced panic attacks had significantly larger increases in plasma MHPG, cortisol, systolic blood pressure, and heart rate than the healthy subjects. These findings support the hypothesis relating high noradrenergic neuronal activity to the pathophysiology of panic attacks in a subgroup of panic disorder patients.
Authors:
D S Charney; S W Woods; W K Goodman; G R Heninger
Related Documents :
6733526 - Baroreceptor-mediated inhibition of a5 noradrenergic neurons.
25097096 - A review of recent findings about stress-relaxation in the respiratory system tissues.
6735626 - Circulatory changes during and after surgical anesthesia in hypertensive patients treat...
8509996 - The oral antihypertensive activity of the methylated derivatives of phenyl-2-aminoethyl...
19959186 - Resuscitation-induced intestinal edema and related dysfunction: state of the science.
18082526 - Simplifying the estimation of jugular venous pressure.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of psychiatry     Volume:  144     ISSN:  0002-953X     ISO Abbreviation:  Am J Psychiatry     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-08-26     Completed Date:  1987-08-26     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370512     Medline TA:  Am J Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1030-6     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Anxiety Disorders / chemically induced*,  metabolism,  physiopathology
Blood Pressure / drug effects
Fear* / drug effects
Female
Heart Rate / drug effects
Humans
Hydrocortisone / blood
Male
Methoxyhydroxyphenylglycol / blood
Norepinephrine / physiology*
Panic* / drug effects
Receptors, Adrenergic, alpha / drug effects
Yohimbine* / pharmacology
Grant Support
ID/Acronym/Agency:
MH-25642/MH/NIMH NIH HHS; MH-36229/MH/NIMH NIH HHS; MH-38007/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Receptors, Adrenergic, alpha; 146-48-5/Yohimbine; 50-23-7/Hydrocortisone; 51-41-2/Norepinephrine; 534-82-7/Methoxyhydroxyphenylglycol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Role of adenosine in regulation of cerebral blood flow: effects of theophylline during normoxia and ...
Next Document:  Effects on fertility of rabbits after active immunization with rat testicular cytochrome ct.