Document Detail


Neurobiological markers of exercise-related brain plasticity in older adults.
MedLine Citation:
PMID:  23123199     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The current study examined how a randomized one-year aerobic exercise program for healthy older adults would affect serum levels of brain-derived neurotrophic factor (BDNF), insulin-like growth factor type 1 (IGF-1), and vascular endothelial growth factor (VEGF) - putative markers of exercise-induced benefits on brain function. The study also examined whether (a) change in the concentration of these growth factors was associated with alterations in functional connectivity following exercise, and (b) the extent to which pre-intervention growth factor levels were associated with training-related changes in functional connectivity. In 65 participants (mean age=66.4), we found that although there were no group-level changes in growth factors as a function of the intervention, increased temporal lobe connectivity between the bilateral parahippocampus and the bilateral middle temporal gyrus was associated with increased BDNF, IGF-1, and VEGF for an aerobic walking group but not for a non-aerobic control group, and greater pre-intervention VEGF was associated with greater training-related increases in this functional connection. Results are consistent with animal models of exercise and the brain, but are the first to show in humans that exercise-induced increases in temporal lobe functional connectivity are associated with changes in growth factors and may be augmented by greater baseline VEGF.
Authors:
Michelle W Voss; Kirk I Erickson; Ruchika Shaurya Prakash; Laura Chaddock; Jennifer S Kim; Heloisa Alves; Amanda Szabo; Siobhan M Phillips; Thomas R Wójcicki; Emily L Mailey; Erin A Olson; Neha Gothe; Victoria J Vieira-Potter; Stephen A Martin; Brandt D Pence; Marc D Cook; Jeffrey A Woods; Edward McAuley; Arthur F Kramer
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural     Date:  2012-11-02
Journal Detail:
Title:  Brain, behavior, and immunity     Volume:  28     ISSN:  1090-2139     ISO Abbreviation:  Brain Behav. Immun.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-14     Completed Date:  2013-06-28     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  8800478     Medline TA:  Brain Behav Immun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  90-9     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Biological Markers / blood
Brain / physiology
Brain-Derived Neurotrophic Factor / blood*,  physiology
Exercise / physiology*
Female
Functional Neuroimaging
Humans
Insulin-Like Growth Factor I / analysis*,  physiology
Magnetic Resonance Imaging
Male
Neuronal Plasticity / physiology*
Neuropsychological Tests
Physical Fitness / physiology
Temporal Lobe / physiology
Vascular Endothelial Growth Factor A / analysis,  blood*
Grant Support
ID/Acronym/Agency:
K25 AG033725/AG/NIA NIH HHS; R01 AG018008/AG/NIA NIH HHS; R01 AG25032/AG/NIA NIH HHS; R37 AG025667/AG/NIA NIH HHS; R37AG025667/AG/NIA NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Brain-Derived Neurotrophic Factor; 0/Vascular Endothelial Growth Factor A; 67763-96-6/Insulin-Like Growth Factor I
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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