| Neurobiological correlates of theory of mind in psychosis proneness. | |
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MedLine Citation:
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PMID: 20888847 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Theory of mind (ToM) refers to the capacity to infer one's own and other persons' mental states. ToM abilities are compromised in schizophrenia, in association with dysfunctional activity in predominantly prefrontal brain regions. Prior behavioral studies have also suggested ToM deficits in healthy individuals with psychosis proneness (PP), although no study to date had investigated the associated neural mechanisms in such a sample. Here we used functional magnetic resonance imaging (fMRI) to compare brain activation of subjects with high versus low scores on positive-dimension PP and a ToM task. The ToM task involved first and second order attribution of cognitive and affective mental states to a cartoon character based on verbal and eye-gaze cues. No between-group differences were found on behavioral performance. fMRI analyses revealed a group interaction in anterior prefrontal cortex (BA 10), with the high PP group showing significantly more activity thereof, relative to the low PP, during second order mentalizing than during first order mentalizing. Further between-group differences were observed in dorsomedial and lateral prefrontal regions (BA 46/9), with the high PP group also showing greater activation during second order mentalizing. These results suggest that subjects with positive-dimension PP require more activation of prefrontal areas to adequately mentalize. Differences in the neural mechanisms underlying ToM might be associated with vulnerability to psychosis. |
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Authors:
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Gemma Modinos; Remco Renken; Simone G Shamay-Tsoory; Johan Ormel; André Aleman |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-01 |
Journal Detail:
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Title: Neuropsychologia Volume: 48 ISSN: 1873-3514 ISO Abbreviation: Neuropsychologia Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-11-08 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0020713 Medline TA: Neuropsychologia Country: England |
Other Details:
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Languages: eng Pagination: 3715-24 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Neuroscience, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. gemma.modinos@kcl.ac.uk |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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