Document Detail

Neurobehavioural dysfunction following mild traumatic brain injury in childhood: a case report with positive findings on positron emission tomography (PET).
MedLine Citation:
PMID:  7550214     Owner:  NLM     Status:  MEDLINE    
The present case study describes the neurobehavioural, neurodiagnostic, and positron emission tomography (PET) scan findings in a child who sustained a whiplash-type injury in a motor vehicle accident. Although neck and back pain were reported immediately, neurobehavioural symptoms, such as staring spells, gradually increased in frequency over a 2-year period following the accident. At 4 years after the accident the patient's symptoms persisted, as reported by teachers and parents, and more extensive diagnostic work-up was initiated. Standard EEG was normal while two ambulatory EEGs were abnormal and interpreted as epileptiform. A PET scan showed evidence of marked hypometabolism in both temporal lobes. Neuropsychological findings were consistent with PET findings and reflected verbal and visual memory deficits in the context of high average intelligence. Treatment with carbamazepine, verapamil, and fluoxetine greatly improved the patient's symptoms. The present case illustrates an example of a poor outcome in a paediatric case of mild traumatic brain injury, the importance of PET in demonstrating definitive evidence of brain dysfunction, and the child's positive response to anticonvulsant medication.
M A Roberts; F F Manshadi; D L Bushnell; M E Hines
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Brain injury     Volume:  9     ISSN:  0269-9052     ISO Abbreviation:  Brain Inj     Publication Date:  1995 Jul 
Date Detail:
Created Date:  1995-11-20     Completed Date:  1995-11-20     Revised Date:  2014-11-14    
Medline Journal Info:
Nlm Unique ID:  8710358     Medline TA:  Brain Inj     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  427-36     Citation Subset:  IM    
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MeSH Terms
Accidents, Traffic
Anticonvulsants / therapeutic use
Antidepressive Agents, Second-Generation / therapeutic use
Brain Concussion / drug therapy,  physiopathology,  radionuclide imaging*
Brain Damage, Chronic / drug therapy,  physiopathology,  radionuclide imaging*
Carbamazepine / therapeutic use
Child Behavior Disorders / drug therapy,  physiopathology,  radionuclide imaging*
Delirium, Dementia, Amnestic, Cognitive Disorders / drug therapy,  physiopathology,  radionuclide imaging*
Electroencephalography / drug effects
Energy Metabolism / drug effects,  physiology*
Epilepsy, Post-Traumatic / drug therapy,  physiopathology,  radionuclide imaging
Fluoxetine / therapeutic use
Follow-Up Studies
Mental Recall / physiology
Neuropsychological Tests
Temporal Lobe / drug effects,  physiopathology,  radionuclide imaging*
Tomography, Emission-Computed*
Vasodilator Agents / therapeutic use
Verapamil / therapeutic use
Whiplash Injuries / drug therapy,  physiopathology,  radionuclide imaging
Reg. No./Substance:
0/Anticonvulsants; 0/Antidepressive Agents, Second-Generation; 0/Vasodilator Agents; 01K63SUP8D/Fluoxetine; 33CM23913M/Carbamazepine; CJ0O37KU29/Verapamil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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