Document Detail

Neurobehavioural disorders in the infant reeler mouse model: interaction of genetic vulnerability and consequences of maternal separation.
MedLine Citation:
PMID:  17141885     Owner:  NLM     Status:  MEDLINE    
Studies on heterozygous (HZ) reeler mice suggest a relationship between reelin (a protein of extra cellular matrix) haploinsufficiency and the presence of altered neural networks and behaviour. Neonatal adverse and/or stimulating experiences might interfere with the emergence of this genetic-dependent phenotype. Repeated episodes of maternal separation early in ontogeny result in enduring neuroendocrine, neurochemical and behavioural alterations in the offspring. Therefore, in order to investigate whether developmental indexes of neurobehavioural disorders can be studied in the infant reeler mouse model, and whether ontogenetic adverse experiences may question or improve its suitability, homozygous reeler (RL), heterozygous (HZ) and wild-type (WT) mouse pups underwent maternal separation (SEP, 5h/day) or handling (H, 3min/day) on PND 2-6. As expected, a sex difference appeared, for measure of emotional and communicative behaviour in infant mice. On PND 7, compared to other genotypes, RL mouse pups from the H control group, showed reduced levels of ultrasound (USV) production and of locomotion. Surprisingly, this deficit in RL mice was fully reverted by maternal separation. Maternal separation per se reduced social motivation in the homing test at PND 9 in WT mice, with no effects on HZ and RL ones. Additionally, female pups emitted much lower levels of ultrasound production than males within the H control group. Such a baseline sex difference, however, disappeared in the SEP group. The present results provide evidence that unusual stress and related hormonal stimulation early in development may (i) independently shape individual phenotype and (ii) interact with a genetic make-up to substantially modify its "natural" developmental trajectories.
Elisa Ognibene; Walter Adriani; Simone Macrì; Giovanni Laviola
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2006-12-04
Journal Detail:
Title:  Behavioural brain research     Volume:  177     ISSN:  0166-4328     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-15     Completed Date:  2007-03-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  142-9     Citation Subset:  IM    
Section of Behavioural Neuroscience, Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Roma, Italy.
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MeSH Terms
Animals, Newborn
Cell Adhesion Molecules, Neuronal / genetics*
Disease Models, Animal
Extracellular Matrix Proteins / genetics*
Homing Behavior / physiology
Maternal Deprivation*
Mental Disorders / genetics*,  physiopathology*
Mice, Neurologic Mutants
Motor Activity / physiology
Nerve Tissue Proteins / genetics*
Reaction Time / genetics
Serine Endopeptidases / genetics*
Vocalization, Animal / physiology
Reg. No./Substance:
0/Cell Adhesion Molecules, Neuronal; 0/Extracellular Matrix Proteins; 0/Nerve Tissue Proteins; EC 3.4.21.-/Serine Endopeptidases; EC 3.4.21.-/reelin protein

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