Document Detail

Neurobehavioral tests in rat models of degenerative brain diseases.
MedLine Citation:
PMID:  20013245     Owner:  NLM     Status:  MEDLINE    
Each translational approach in medical research forces the establishment of neurobehavioral screening systems, dedicated to fill the gap between postgenomic generation of state-of-the-art animal models (i.e. transgenic rats) on the one hand and their added value for really predictive experimental preclinical therapy on the other. Owing to these developments in the field, neuroscientists are frequently challenged by the task of detecting discrete behavioral differences in rats. Systematic, comprehensive phenotyping covers these needs and represents a central part of the process. In this chapter, we provide an overview on theoretical issues related to comprehensive neurobehavioral phenotyping of rats and propose specific classical procedures, protocols (similar to the SHIRPA approach in mice), as well as techniques for repeated, intraindividual phenotyping. Neurological testing of rats, motorfunctional screening using the accelerod approach, emotional screening using the social interaction test of anxiety, and testing of sensorimotoric gating functions by prepulse inhibition of the startle response are provided in more detail. This description is completed by an outlook on most recent developments in the field dealing with automated, intra-home-cage technologies, allowing continuous screening in rats in various behavioral and physiological dimensions on an ethological basis.
Yvonne K Urbach; Felix J Bode; Huu Phuc Nguyen; Olaf Riess; Stephan von H?rsten
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Methods in molecular biology (Clifton, N.J.)     Volume:  597     ISSN:  1940-6029     ISO Abbreviation:  Methods Mol. Biol.     Publication Date:  2010  
Date Detail:
Created Date:  2009-12-16     Completed Date:  2010-02-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9214969     Medline TA:  Methods Mol Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  333-56     Citation Subset:  IM    
Franz-Penzoldt-Center, Experimental Therapy, Friedrich-Alexander-University of Erlangen-N?rnberg, Erlangen, Germany.
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MeSH Terms
Behavior, Animal*
Brain Diseases / psychology
Disease Models, Animal*
Neurodegenerative Diseases / psychology*
Rats / psychology*
Rats, Transgenic / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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