Document Detail

Neurobehavioral risk is associated with gestational exposure to stress hormones.
MedLine Citation:
PMID:  23144647     Owner:  NLM     Status:  Publisher    
The developmental origins of disease or fetal programming model predict that early exposures to threat or adverse conditions have lifelong consequences that result in harmful outcomes for health. The maternal endocrine 'fight or flight' system is a source of programming information for the human fetus to detect threats and adjust their developmental trajectory for survival. Fetal exposures to intrauterine conditions including elevated stress hormones increase the risk for a spectrum of health outcomes depending on the timing of exposure, the timetable of organogenesis and the developmental milestones assessed. Recent prospective studies, reviewed here, have documented the neurodevelopmental consequences of fetal exposures to the trajectory of stress hormones over the course of gestation. These studies have shown that fetal exposures to biological markers of adversity have significant and largely negative consequences for fetal, infant and child emotional and cognitive regulation and reduced volume in specific brain structures.
Curt A Sandman; Elysia Poggi Davis
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Publication Detail:
Journal Detail:
Title:  Expert review of endocrinology & metabolism     Volume:  7     ISSN:  1744-6651     ISO Abbreviation:  Expert Rev Endocrinol Metab     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-11-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101278293     Medline TA:  Expert Rev Endocrinol Metab     Country:  -    
Other Details:
Languages:  ENG     Pagination:  445-459     Citation Subset:  -    
Department of Psychiatry & Human Behavior, Women and Children's Health and Well-Being Project, University of California, Irvine, Orange, CA, USA.
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