Document Detail


Neurobehavioral effects of prenatal exposure to methylmercury and PCBs, and seafood intake: neonatal behavioral assessment scale results of Tohoku study of child development.
MedLine Citation:
PMID:  20673887     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
As factors affecting neonatal neurodevelopment, methylmercury, polychlorinated biphenyls (PCBs), and maternal seafood intake reflecting n-3 polyunsaturated fatty acids (PUFAs) are believed to have adverse or beneficial effects, but there are a few reports addressing such factors simultaneously. We carried out a birth cohort study to clarify the effects of these three factors on the Neonatal Behavioral Assessment Scale (NBAS), administered 3 days after birth. In a total of 498 mother-neonate pairs, the total mercury level (median, 1.96microg/g) in maternal hair at parturition and the summation operatorPCB level (45.5ng/g-lipid) in cord blood were analyzed, and maternal seafood intake was estimated using a semi-quantitative food frequency questionnaire. A negative relationship between the hair mercury level and the motor cluster of NBAS was observed, even after adjusting for PCBs, maternal seafood intake, and possible confounders such as maternal age, birth weight, and parity. The summation operatorPCB level was negatively correlated with the motor cluster, but this association was attenuated after adjusting for mercury and the confounders. There was seen to be a positive association between maternal seafood intake and the motor cluster when considering the effects of mercury and PCBs. In conclusion, our data suggest that prenatal exposure to methylmercury adversely affects neonatal neurobehavioral function; in contrast, maternal seafood intake appears to be beneficial. The neurobehavioral effect of prenatal exposure to PCBs remains unclear in our study. Further research is necessary to elucidate interactive effects of methylmercury, PCBs, and n-3 PUFAs, originating from fish, on child neurodevelopment.
Authors:
Keita Suzuki; Kunihiko Nakai; Tomoko Sugawara; Tomoyuki Nakamura; Takashi Ohba; Miyuki Shimada; Toru Hosokawa; Kunihiro Okamura; Takeo Sakai; Naoyuki Kurokawa; Katsuyuki Murata; Chieko Satoh; Hiroshi Satoh
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-01
Journal Detail:
Title:  Environmental research     Volume:  110     ISSN:  1096-0953     ISO Abbreviation:  Environ. Res.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-08-31     Completed Date:  2010-09-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0147621     Medline TA:  Environ Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  699-704     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Inc. All rights reserved.
Affiliation:
Environmental Health Sciences, Tohoku University, Graduate School of Medicine, 2-1 Seiryo-machi, Sendai, Miyagi 980-8576, Japan; Japan Society for the Promotion of Science, Tokyo, Japan.
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MeSH Terms
Descriptor/Qualifier:
Adult
Female
Humans
Infant Behavior*
Infant, Newborn
Maternal Exposure*
Methylmercury Compounds / toxicity*
Polychlorinated Biphenyls / toxicity*
Pregnancy
Seafood*
Chemical
Reg. No./Substance:
0/Methylmercury Compounds; 0/Polychlorinated Biphenyls

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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