Document Detail

Neurobehavioral effects of long-term occupational exposure to organic solvents: two comparable studies.
MedLine Citation:
PMID:  1519617     Owner:  NLM     Status:  MEDLINE    
Two comparable cross-sectional studies were carried out employing the same methodology but involving two separate solvent-exposed populations (N = 90, N = 144). In each study, solvent-exposed workers were compared with age-matched controls on tests selected from the Neurobehavioral Evaluation System and on standardized questionnaire measures of symptomatology and psychiatric state. A similar pattern of results was obtained in the two studies indicating a significant effect on cognitive functioning, after controlling for confounding variables, occurring in those with more than 30 years of exposure. A more specific effect on learning processes was observed in those with more than 10 years of exposure. There were no indications in either study of a solvent-related increase in psychiatric symptoms.
A Spurgeon; C N Gray; J Sims; I Calvert; L S Levy; P G Harvey; J M Harrington
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of industrial medicine     Volume:  22     ISSN:  0271-3586     ISO Abbreviation:  Am. J. Ind. Med.     Publication Date:  1992  
Date Detail:
Created Date:  1992-10-08     Completed Date:  1992-10-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8101110     Medline TA:  Am J Ind Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  325-35     Citation Subset:  IM    
Institute of Occupational Health, University of Birmingham, Edgbaston, England.
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MeSH Terms
Analysis of Variance
Brain / drug effects
Cognition Disorders / chemically induced
Cross-Sectional Studies
Learning Disorders / chemically induced
Mental Disorders / chemically induced*
Middle Aged
Occupational Diseases / chemically induced*
Occupational Exposure*
Paint / adverse effects
Psychological Tests
Solvents / adverse effects*
Time Factors
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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