Document Detail

Neurobehavioral development following aluminum administration in infant rabbits.
MedLine Citation:
PMID:  3996513     Owner:  NLM     Status:  MEDLINE    
Aluminum (Al) is known to be a neurotoxic agent in some species, inducing neurofibrillary tangles, dendritic atrophy, and behavioral deterioration, and has been implicated as a possible agent in human Alzheimer's disease and dialysis dementia. This study was conducted to assess the neurotoxic effects of Al in infant rabbits, and to compare the effects to those previously observed to follow exposure in the adult animal. Aluminum tartrate (2 microM) or physiologic saline was injected into the right lateral ventricle of 2-day-old (day P3) New Zealand white rabbits. The animals were trained in a step-down active avoidance task on P12 and retested 1 day later. They were killed on P20, and their hippocampal CA1 pyramidal cells examined for neurofibrillary tangles or prepared with the rapid Golgi stain for an examination of dendritic development. Additional animals were similarly infused with 1 or 3 microM Al for qualitative and some quantitative observations. No overt neurologic signs were observed in the 1- or 2-microM groups, however, most of the 3-microM group died between P10 and P20. Although there were no significant differences between the 2-microM and control animals on either learning or retention of the active avoidance task, deficits in retention of the task were observed in the 3-microM group. Neurofibrillary tangles in CA1 pyramidal cells were observed with dosages of 1 microM and higher. In the 2-microM group, the pattern of dendritic arborization in CA1 pyramidal cells was consistent with that expected for cells retarded in their development. These results have implications in terms of developmental differences in the neurobehavioral effects of Al.
T L Petit; G B Biederman; P Jonas; J C LeBoutillier
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Experimental neurology     Volume:  88     ISSN:  0014-4886     ISO Abbreviation:  Exp. Neurol.     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-07-12     Completed Date:  1985-07-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370712     Medline TA:  Exp Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  640-51     Citation Subset:  IM    
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MeSH Terms
Aluminum / pharmacology*
Animals, Newborn / growth & development*
Behavior, Animal / drug effects*
Body Weight / drug effects
Brain / anatomy & histology
Dendrites / ultrastructure
Hippocampus / anatomy & histology,  ultrastructure
Microscopy, Electron
Nervous System / growth & development*
Neurofibrils / ultrastructure
Organ Size / drug effects
Reg. No./Substance:

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