Document Detail


Neurobehavioral deficits in neonatal rhesus monkeys exposed to cocaine in utero.
MedLine Citation:
PMID:  15001210     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In spite of significant efforts, the neurobehavioral deficits in infants born from cocaine-abusing mothers have not been clearly defined. In the present study, we examined the presence of these abnormalities in a rhesus monkey model of prenatal cocaine exposure using a nonhuman primate adaptation of the Neonatal Behavioral Assessment Scale (NBAS). Pregnant monkeys (n = 14) received 10 mg/kg cocaine twice a day orally (in fruit treats) from the 40th through 102nd postconception days (PCD40-PCD102), which is the period of cerebral cortical neuronogenesis (approximately second trimester). The control consisted of pregnant monkeys (n = 14) receiving fruit treats only. The animals were allowed to deliver vaginally at term (approximately PCD165). The first testing session was conducted on PCD171 (within the first week after birth); the second testing session was conducted on PCD177 (within the second week after birth); the third test was conducted on PCD183 (within the third week after birth); and the fourth testing session was conducted on PCD189 (within the fourth week after birth). The prenatally cocaine-exposed infants showed deficits in orientation, state control, and motor maturity, which were detectable during the second, third, and fourth testing sessions. The same testing sessions also revealed a significant reduction in the time devoted to toy manipulation, which points to impaired attention. None of these abnormalities were seen during the first testing session. The first session, however, revealed increased tremulousness (one of the indicators of autonomic stability) in the prenatally cocaine-exposed infants. This impairment disappeared by the third testing session. The present findings demonstrate the potential of prenatal cocaine exposure to induce neurobehavioral deficits detectable by NBAS-like testing in primate infants.
Authors:
Na He; Jie Bai; Maribeth Champoux; Stephen J Suomi; Michael S Lidow
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurotoxicology and teratology     Volume:  26     ISSN:  0892-0362     ISO Abbreviation:  Neurotoxicol Teratol     Publication Date:    2004 Jan-Feb
Date Detail:
Created Date:  2004-03-05     Completed Date:  2004-05-12     Revised Date:  2009-10-26    
Medline Journal Info:
Nlm Unique ID:  8709538     Medline TA:  Neurotoxicol Teratol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  13-21     Citation Subset:  IM    
Affiliation:
Department of Biomedical Sciences, Neuroscience Division, University of Maryland, Baltimore, 5-A-12, HHH, 666 W. Baltimore Street, Baltimore, MD 21201, USA.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Anesthetics, Local / toxicity*
Animals
Behavior, Animal / drug effects*
Behavioral Symptoms / chemically induced*
Cocaine / toxicity*
Female
Macaca mulatta
Male
Neuropsychological Tests
Pregnancy
Pregnancy Complications / physiopathology
Prenatal Exposure Delayed Effects*
Psychomotor Performance / drug effects
Time Factors
Grant Support
ID/Acronym/Agency:
R01 DA08057/DA/NIDA NIH HHS
Chemical
Reg. No./Substance:
0/Anesthetics, Local; 50-36-2/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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