Document Detail

Neurobehavioral assessment predicts differential outcome between VLBW and ELBW preterm infants.
MedLine Citation:
PMID:  16292337     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the impact of birth weight on development of very low birth weight (VLBW) infants using the Neurobehavioral Assessment of the Preterm Infant (NAPI) before hospital discharge, and to show the relation to follow-up outcomes at 12, 18 and 30 months of age. STUDY DESIGN: In total, 113 preterm infants were assessed with the NAPI at 36 weeks postmenstrual age. Later, neurodevelopment was examined using the Bayley Infant Neurodevelopmental Screener (BINS) at 12 months and the Bayley Scales of Infant Development, at 18 and 30 months. The cohort was divided into two groups, based on birth weight, extremely low birth weight (ELBW) (<1000 g) and VLBW (1000 to 1500 g). RESULTS: ELBW infants showed significantly lower NAPI scores compared with VLBW infants at 36 weeks. The predischarge NAPI scores correlated with the 12, 18 and 30 months scores when the ELBW infants continue to have lower performance than the VLBW infants. In all, 14 infants developed cerebral palsy. These infants had significantly lower NAPI, BINS and Bayley scores compared with all other preterm infants. CONCLUSION: NAPI before discharge provides clinically meaningful information related to later neurodevelopmental outcome.
Janet C Constantinou; Elvidina N Adamson-Macedo; Majid Mirmiran; Ronald L Ariagno; Barry E Fleisher
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of perinatology : official journal of the California Perinatal Association     Volume:  25     ISSN:  0743-8346     ISO Abbreviation:  J Perinatol     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-11-28     Completed Date:  2006-03-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8501884     Medline TA:  J Perinatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  788-93     Citation Subset:  IM    
Division of Neonatal and Developmental Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
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MeSH Terms
Birth Weight
Brain Damage, Chronic / diagnosis*,  epidemiology
Cerebral Palsy / diagnosis,  epidemiology
Cohort Studies
Developmental Disabilities / diagnosis*,  epidemiology
Follow-Up Studies
Gestational Age
Infant Behavior*
Infant, Newborn
Infant, Premature, Diseases / diagnosis*,  epidemiology
Infant, Very Low Birth Weight*
Neurologic Examination / statistics & numerical data*
Psychomotor Disorders / diagnosis*,  epidemiology
Reproducibility of Results
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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