Document Detail

Neurobehavioral assessment predicts motor outcome in preterm infants.
MedLine Citation:
PMID:  19880137     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To determine whether Neonatal Intensive Care Unit Network Neurobehavior Scales (NNNS) at 44 weeks predict motor outcome at 2 years in preterm infants from the Maternal Lifestyles Study (MLS).
STUDY DESIGN: Data were collected on all preterm infants (<36 weeks) in the MLS who underwent an NNNS at 44 weeks (n = 395) and neurologic examination at 12 to 36 months or Bayley Psychomotor Development Index (PDI) at 24 months (n = 270). Logistic regression analyzed NNNS summary scores associated with cerebral palsy (CP) or PDI <70, while controlling for birth weight </=1250 g.
RESULTS: Eighteen of 395 infants (5%) had CP; 24 of 270 infants (9%) had PDI <70. CP was associated with low quality of movement (odds ratio [OR], 1.95; 95% CI, 1.24-3.06; P = .004) and high lethargy (OR, 1.67; 95% CI, 1.01-2.76; P = .045). The model contributed 19% of the variance in CP diagnosis at 12 to 36 months (R(2) = .19, P < .001). Low PDI was associated with low handling (OR, 1.83; 95% CI, 1.12-2.99; P = .017), low quality of movement (OR, 2.16; 95% CI, 1.38-3.38; P = .001), and hypotonia (OR, 1.63; 95% CI, 1.14-2.32; P = .007). The model contributed 26% of the variance in PDI <70 at 24 months (R(2) = 0.26, P < .001).
CONCLUSIONS: The neurobehavioral profile of under-arousal in 44-week-old preterm infants may predict poor motor outcome.
Bonnie E Stephens; Jing Liu; Barry Lester; Linda Lagasse; Seetha Shankaran; Henrietta Bada; Charles Bauer; Abhik Das; Rosemary Higgins
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2009-11-01
Journal Detail:
Title:  The Journal of pediatrics     Volume:  156     ISSN:  1097-6833     ISO Abbreviation:  J. Pediatr.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-23     Completed Date:  2010-03-23     Revised Date:  2014-09-24    
Medline Journal Info:
Nlm Unique ID:  0375410     Medline TA:  J Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  366-71     Citation Subset:  AIM; IM    
Copyright Information:
Copyright 2010 Mosby, Inc. All rights reserved.
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MeSH Terms
Cerebral Palsy / diagnosis*
Child, Preschool
Cocaine-Related Disorders
Developmental Disabilities / diagnosis*
Infant Behavior*
Infant, Extremely Low Birth Weight
Infant, Newborn
Infant, Premature*
Neurologic Examination*
Predictive Value of Tests
Pregnancy Complications
Young Adult
Grant Support
U10 DA024117/DA/NIDA NIH HHS; U10 DA024117-01/DA/NIDA NIH HHS; U10 DA024117-02/DA/NIDA NIH HHS; U10 DA024117-03/DA/NIDA NIH HHS; U10 DA024117-04/DA/NIDA NIH HHS; U10 DA024118-01/DA/NIDA NIH HHS; U10 DA024118-02/DA/NIDA NIH HHS; U10 DA024118-03/DA/NIDA NIH HHS; U10 DA024118-04/DA/NIDA NIH HHS; U10 DA024119/DA/NIDA NIH HHS; U10 DA024119-01/DA/NIDA NIH HHS; U10 DA024119-02/DA/NIDA NIH HHS; U10 DA024119-02S1/DA/NIDA NIH HHS; U10 DA024119-02S2/DA/NIDA NIH HHS; U10 DA024119-03/DA/NIDA NIH HHS; U10 DA024119-04/DA/NIDA NIH HHS; U10 DA024128-06/DA/NIDA NIH HHS; U10 DA024128-07/DA/NIDA NIH HHS; U10 DA024128-08/DA/NIDA NIH HHS; U10 DA024128-09/DA/NIDA NIH HHS; U10 HD021385/HD/NICHD NIH HHS; U10 HD021385-17S1/HD/NICHD NIH HHS; U10 HD021385-18S1/HD/NICHD NIH HHS; U10 HD021385-19S2/HD/NICHD NIH HHS; U10 HD021385-20S1/HD/NICHD NIH HHS; U10 HD042638-03/HD/NICHD NIH HHS; U10 HD042638-04/HD/NICHD NIH HHS; U10 HD042638-04S1/HD/NICHD NIH HHS
Comment In:
J Pediatr. 2010 Mar;156(3):347-9   [PMID:  20176181 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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