Document Detail

Neuroanatomy of Down's syndrome: a high-resolution MRI study.
MedLine Citation:
PMID:  11578999     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Down's syndrome, the most common genetic cause of mental retardation, results in characteristic physical and neuropsychological findings, including mental retardation and deficits in language and memory. This study was undertaken to confirm previously reported abnormalities of regional brain volumes in Down's syndrome by using high-resolution magnetic resonance imaging (MRI), determine whether these volumetric abnormalities are present from childhood, and consider the relationship between neuroanatomic abnormalities and the cognitive profile of Down's syndrome. METHOD: Sixteen children and young adults with Down's syndrome (age range=5-23 years) were matched for age and gender with 15 normal comparison subjects. High-resolution MRI scans were quantitatively analyzed for measures of overall and regional brain volumes and by tissue composition. RESULTS: Consistent with prior imaging studies, subjects with Down's syndrome had smaller overall brain volumes, with disproportionately smaller cerebellar volumes and relatively larger subcortical gray matter volumes. Also noted was relative preservation of parietal lobe gray and temporal lobe white matter in subjects with Down's syndrome versus comparison subjects. No abnormalities in pattern of brain asymmetry were noted in Down's syndrome subjects. CONCLUSIONS: The results largely confirm findings of previous studies with respect to overall patterns of brain volumes in Down's syndrome and also provide new evidence for abnormal volumes of specific regional tissue components. The presence of these abnormalities from an early age suggests that fetal or early postnatal developmental differences may underlie the observed pattern of neuroanatomic abnormalities and contribute to the specific cognitive and developmental deficits seen in individuals with Down's syndrome.
J D Pinter; S Eliez; J E Schmitt; G T Capone; A L Reiss
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of psychiatry     Volume:  158     ISSN:  0002-953X     ISO Abbreviation:  Am J Psychiatry     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-10-01     Completed Date:  2001-11-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0370512     Medline TA:  Am J Psychiatry     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1659-65     Citation Subset:  AIM; IM    
Department of Neurology, University of California, San Francisco, USA.
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MeSH Terms
Age Factors
Brain / anatomy & histology*
Cerebellum / anatomy & histology
Child, Preschool
Down Syndrome / diagnosis*
Frontal Lobe / anatomy & histology
Magnetic Resonance Imaging / statistics & numerical data*
Parietal Lobe / anatomy & histology
Temporal Lobe / anatomy & histology
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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