Document Detail


Neuroanatomical and neurocognitive differences in a pair of monozygous twins discordant for strictly defined autism.
MedLine Citation:
PMID:  9629848     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this study, we investigated the neuroanatomical similarities and differences between a pair of monozygotic, 7.5-year-old twin boys discordant for strictly defined autism, to identify neuroanatomical pathways that are impaired in individuals with autism. Although the unaffected twin did not fulfill the traditional diagnostic criteria for autism, he displayed constrictions in social interaction and play that were consistent with the broader phenotype for autism that has been described in nonautistic co-twins. Magnetic resonance imaging scans were obtained for each brother and compared with the scans of 5 age- and sex-matched unaffected peers. Quantitative analysis of brain anatomy revealed that the affected twin had markedly smaller caudate, amygdaloid, and hippocampal volumes, and smaller cerebellar vermis lobules VI and VII, in comparison with his brother. Both twins evidenced disproportionately reduced volumes of the superior temporal gyrus and the frontal lobe relative to the comparison sample. The results suggest the dysfunction of two separate but overlapping neuroanatomical pathways, ie, one subcortical network differentiating the twins from each other that may underlie the traditional neurobehavioral phenotype for strictly defined autism, and a second cortical network differentiating the twins from the comparison sample that may lead to the broader phenotype for autism.
Authors:
W R Kates; S H Mostofsky; A W Zimmerman; M M Mazzocco; R Landa; I S Warsofsky; W E Kaufmann; A L Reiss
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Twin Study    
Journal Detail:
Title:  Annals of neurology     Volume:  43     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1998-06-25     Completed Date:  1998-06-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  782-91     Citation Subset:  IM    
Affiliation:
Kennedy Krieger Institute, and Department of Psychiatry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
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MeSH Terms
Descriptor/Qualifier:
Autistic Disorder / diagnosis,  genetics,  pathology*
Brain / pathology*,  physiopathology
Caudate Nucleus / pathology,  physiopathology
Cerebellum / pathology,  physiopathology
Cerebral Cortex / pathology,  physiopathology
Child
Cognition Disorders / diagnosis,  genetics,  pathology*
Genotype
Humans
Magnetic Resonance Imaging
Male
Neuropsychological Tests
Phenotype
Temporal Lobe / pathology,  physiopathology
Twins, Monozygotic*
Grant Support
ID/Acronym/Agency:
HD 31715/HD/NICHD NIH HHS; MH01142/MH/NIMH NIH HHS; MH50047/MH/NIMH NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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