Document Detail

Neuroanatomical correlates of neurological soft signs in antipsychotic-naive schizophrenia.
MedLine Citation:
PMID:  19019637     Owner:  NLM     Status:  MEDLINE    
Recent imaging studies suggest that the so-called "soft" neurological signs in schizophrenia might have neuroanatomical validity. We examined gray matter volume correlates of neurological soft signs (NSS) in antipsychotic-naive schizophrenia patients using an automated image analysis technique. NSS were assessed using a modified neurological evaluation scale with good inter-rater reliability. Magnetic resonance images of 30 schizophrenia patients and 27 age-, sex-, education- and handedness-matched healthy controls were processed using optimized voxel-based morphometry (VBM). Logistic regression analysis showed that only the Motor Sequencing Signs (MSS) sub-score was a significant predictor of subject's status among the NSS sub-scores. Optimized VBM analysis showed that the MSS sub-score had a significant negative correlation with total and regional gray matter volumes (prefrontal, posterior cingulate, temporal cortices, putamen, and cerebellum) in schizophrenia patients but not in controls. Prefrontal and temporal cortices, putamen and cerebellum had significant volume deficits in patients. Cortical and cerebellar correlates of the sub-score MSS support the concept of "cognitive dysmetria" in schizophrenia.
Ganesan Venkatasubramanian; Peruvumba N Jayakumar; Bangalore N Gangadhar; Matcheri S Keshavan
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Psychiatry research     Volume:  164     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-25     Completed Date:  2009-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  215-22     Citation Subset:  IM    
Department of Psychiatry, National Institute of Mental Health and Neurosciences, Bangalore: 5600 29, India.
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MeSH Terms
Brain / anatomy & histology*,  physiopathology*
Cerebellum / anatomy & histology,  physiopathology
Cognition Disorders / diagnosis*,  epidemiology*
Diagnostic and Statistical Manual of Mental Disorders
Prefrontal Cortex / anatomy & histology,  physiopathology
Putamen / anatomy & histology,  physiopathology
Schizophrenia / epidemiology*,  physiopathology*
Temporal Lobe / anatomy & histology,  physiopathology

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