Document Detail

Neuroamine related compounds in the CSF of hydrocephalic rabbits.
MedLine Citation:
PMID:  8541478     Owner:  NLM     Status:  MEDLINE    
The effects of neonatal hydrocephalus on the levels of tyrosine, tryptophan, 5-hydroxyindoleacetic acid (5-HIAA), and homovanillic acid (HVA) in CSF were determined by high-performance liquid chromatography (HPLC) with fluorometric detection in normal and chronically hydrocephalic rabbits. The hydrocephalic rabbits showed a highly significant increase in both the serotonin metabolite 5-HIAA and the dopamine metabolite HVA. There were no significant effects of the hydrocephalus on either tyrosine or tryptophan levels. There was a significant positive correlation between the intracranial pressure (ICP) and the increase in 5-HIAA and HVA, but not with the two precursor amino acids. There was a significant decrease in these amino acid precursors with age in both groups. A trend towards higher levels of 5-HIAA and HVA in older rabbits was also evident, however this change was not to the degree found in the hydrocephalics. These data indicate that increased ICP affects the mechanism of removal of 5-HIAA and HVA from the cerebrospinal fluid.
C E Olmstead; J A Lazareff; E N Orlino; A L Fluharty; K F Faull; W J Peacock; M C Wehby-Grant; R J Gayek; R S Fisher
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Neuroreport     Volume:  6     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1996-02-13     Completed Date:  1996-02-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1769-72     Citation Subset:  IM    
Department of Surgery (Division of Neurosurgery), UCLA School of Medicine 90095, USA.
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MeSH Terms
Aging / cerebrospinal fluid
Analysis of Variance
Chromatography, High Pressure Liquid
Homovanillic Acid / cerebrospinal fluid*
Hydrocephalus / cerebrospinal fluid*
Hydroxyindoleacetic Acid / cerebrospinal fluid*
Tryptophan / cerebrospinal fluid*
Tyrosine / cerebrospinal fluid*
Reg. No./Substance:
306-08-1/Homovanillic Acid; 54-16-0/Hydroxyindoleacetic Acid; 55520-40-6/Tyrosine; 73-22-3/Tryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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