| Neuroadipology: a novel component of neuroendocrinology. | |
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MedLine Citation:
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PMID: 20825365 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Adipose tissue is a dynamic endocrine and paracrine organ producing a large number of signalling proteins collectively termed adipokines. Some of them are mediators in the cross-talk between adipose tissue and the brain in regulating food intake and energy homoeostasis. However, the hypothalamus is not the only brain target for adipokines, and food intake is not the only biological effect of these signals. Rather, some adipokines support various cognitive functions and exert neurotrophic activity. Current data on adipose-derived neuropeptides, neurotrophic factors, pituitary hormones and hypothalamic releasing factors is highlighted in this review. We propose that adipose tissue is a member of the diffuse neuroendocrine system. Cumulatively, this is conceptualized as neuroadipology, a new example of a link between neurobiology and other topics, such as neuroimmunology and neuroendocrinology. Because adipose tissue is a bona fide endocrine organ, neuroadipology may be considered a new discipline in neuroendocrinology. It may have a wide-ranging potential within a variety of neuronal and metabolic functions in health and disease. |
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Authors:
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George N Chaldakov; Marco Fiore; Anton B Tonchev; Luigi Aloe |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Cell biology international Volume: 34 ISSN: 1095-8355 ISO Abbreviation: Cell Biol. Int. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-09-09 Completed Date: 2011-01-10 Revised Date: 2012-08-02 |
Medline Journal Info:
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Nlm Unique ID: 9307129 Medline TA: Cell Biol Int Country: England |
Other Details:
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Languages: eng Pagination: 1051-3 Citation Subset: IM |
Affiliation:
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Division of Cell Biology, Medical University, Varna, Bulgaria. chaldakov@yahoo.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipokines
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physiology Adipose Tissue / physiology* Brain / physiology Cognition Eating Humans Nerve Growth Factors / physiology Neuroendocrinology* Neuroimmunomodulation Neuropeptides / physiology Neurosecretory Systems / physiology* Pituitary Hormone-Releasing Hormones / physiology Pituitary Hormones / physiology Signal Transduction |
| Chemical | |
Reg. No./Substance:
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0/Adipokines; 0/Nerve Growth Factors; 0/Neuropeptides; 0/Pituitary Hormone-Releasing Hormones; 0/Pituitary Hormones |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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