Document Detail

Neuroadipology: a novel component of neuroendocrinology.
MedLine Citation:
PMID:  20825365     Owner:  NLM     Status:  MEDLINE    
Adipose tissue is a dynamic endocrine and paracrine organ producing a large number of signalling proteins collectively termed adipokines. Some of them are mediators in the cross-talk between adipose tissue and the brain in regulating food intake and energy homoeostasis. However, the hypothalamus is not the only brain target for adipokines, and food intake is not the only biological effect of these signals. Rather, some adipokines support various cognitive functions and exert neurotrophic activity. Current data on adipose-derived neuropeptides, neurotrophic factors, pituitary hormones and hypothalamic releasing factors is highlighted in this review. We propose that adipose tissue is a member of the diffuse neuroendocrine system. Cumulatively, this is conceptualized as neuroadipology, a new example of a link between neurobiology and other topics, such as neuroimmunology and neuroendocrinology. Because adipose tissue is a bona fide endocrine organ, neuroadipology may be considered a new discipline in neuroendocrinology. It may have a wide-ranging potential within a variety of neuronal and metabolic functions in health and disease.
George N Chaldakov; Marco Fiore; Anton B Tonchev; Luigi Aloe
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cell biology international     Volume:  34     ISSN:  1095-8355     ISO Abbreviation:  Cell Biol. Int.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-09     Completed Date:  2011-01-10     Revised Date:  2012-08-02    
Medline Journal Info:
Nlm Unique ID:  9307129     Medline TA:  Cell Biol Int     Country:  England    
Other Details:
Languages:  eng     Pagination:  1051-3     Citation Subset:  IM    
Division of Cell Biology, Medical University, Varna, Bulgaria.
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MeSH Terms
Adipokines / physiology
Adipose Tissue / physiology*
Brain / physiology
Nerve Growth Factors / physiology
Neuropeptides / physiology
Neurosecretory Systems / physiology*
Pituitary Hormone-Releasing Hormones / physiology
Pituitary Hormones / physiology
Signal Transduction
Reg. No./Substance:
0/Adipokines; 0/Nerve Growth Factors; 0/Neuropeptides; 0/Pituitary Hormone-Releasing Hormones; 0/Pituitary Hormones

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