Document Detail

Neuroactive properties of reproductive steroids.
MedLine Citation:
PMID:  17850537     Owner:  NLM     Status:  MEDLINE    
Migraine is 3 times more common in postpubertal women than in men. Migraine is frequently exacerbated perimenstrually and commonly occurs exclusively at that time. It is often benefited by pregnancy and menopause. Estrogen withdrawal has been implicated as a mechanism for triggering migraines. The mechanism, however, is not well understood. Reproductive steroids have neuroactive properties that can modulate neuronal morphology and physiology. Increasing evidence suggests that circulating reproductive steroid levels regulate the balance of neuroexcitatory and neuroinhibitory activities in some brain regions by influencing synaptic plasticity. Estrogen has neuroexcitatory, whereas progesterone has neuroinhibitory, effects in most preclinical and clinical models. Several neurotransmitter systems that are implicated in migraine vary with reproductive steroid levels during the reproductive cycle. Estrogen stabilization may provide effective treatment in susceptible women, especially for catamenially exacerbated migraine.
Andrew G Herzog
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Headache     Volume:  47 Suppl 2     ISSN:  0017-8748     ISO Abbreviation:  Headache     Publication Date:  2007 Sep 
Date Detail:
Created Date:  2007-09-13     Completed Date:  2007-11-20     Revised Date:  2009-02-02    
Medline Journal Info:
Nlm Unique ID:  2985091R     Medline TA:  Headache     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S68-78     Citation Subset:  IM    
Harvard Medical School, Harvard Neuroendocrine Unit, Beth Israel Deaconess Medical Center, Boston, MA, USA.
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MeSH Terms
Estrogens / physiology
Gonadal Steroid Hormones / physiology*
Migraine Disorders / physiopathology
Nervous System Physiological Phenomena*
Neurons / physiology*,  ultrastructure
Reg. No./Substance:
0/Estrogens; 0/Gonadal Steroid Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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