Document Detail

Neuroactive pregnanolone isomers during pregnancy.
MedLine Citation:
PMID:  15486056     Owner:  NLM     Status:  MEDLINE    
The pregnanolone isomers (PI) allopregnanolone (3alpha-hydroxy-5alpha-pregnan-20-one), pregnanolone (3alpha-hydroxy-5beta-pregnan-20-one), isopregnanolone (3beta-hydroxy-5alpha-pregnan-20-one), epipregnanolone (3beta-hydroxy-5beta-pregnan-20-one), progesterone, and estradiol were measured in 138 pregnant women. The sampling was carried out from the first through the 10th month of pregnancy. Gas chromatography-mass spectrometry analysis and RIA were used for the measurement of steroid levels. The ratios of individual PI were similar to those found previously around parturition: about 25:10:7:1 for allopregnanolone, pregnanolone, isopregnanolone, and epipregnanolone, respectively. All the PI showed a significant increase during pregnancy, which was more pronounced in the 3alpha-steroids. The results indicated changing ratios between 3alpha- and 3beta-PI and between 5alpha- and 5beta-PI throughout pregnancy. The constant allopregnanolone/isopregnanolone ratio found through pregnancy weakened the hypothesis of the role of isopregnanolone in the onset of parturition. The ratio of estradiol (stimulating uterine activity) to 5alpha-PI and epipregnanolone exhibited significant changes during pregnancy in favor of estradiol up to the sixth or seventh month, in contrast to the constant estradiol/pregnanolone ratio. A pregnancy-stabilizing role of pregnanolone, counterbalancing the stimulating effect of estradiol on the onset of parturition, was suggested.
Antonín Parízek; Martin Hill; Radmila Kancheva; Helena Havlíková; Lyudmila Kancheva; Josef Cindr; Andrea Pasková; Vladimír Pouzar; Ivan Cerny; Pavel Drbohlav; Zdenek Hájek; Luboslav Stárka
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2004-10-14
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  90     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-01-11     Completed Date:  2005-02-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  395-403     Citation Subset:  AIM; IM    
Department of Gynecology and Obstetrics, First Medical Faculty, Charles University, Prague 1, Czech Republic.
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MeSH Terms
Estradiol / blood
Gestational Age
Labor, Obstetric / blood
Pregnancy / blood*
Pregnanolone / blood*
Progesterone / blood
Reg. No./Substance:
128-20-1/Pregnanolone; 50-28-2/Estradiol; 57-83-0/Progesterone

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