| Neuro-ophthalmic findings in the visual variant of Alzheimer's disease. | |
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MedLine Citation:
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PMID: 15019393 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To describe the clinical features of a visual variant Alzheimer's disease, a disorder that might be seen by the ophthalmologist with visual symptoms and signs. DESIGN: Retrospective case series. PARTICIPANTS: Eight patients with Alzheimer's disease presenting with predominantly visual complaints. METHODS: A retrospective review of patients at a tertiary care academic center seen by the authors from 1999 to 2001 with Alzheimer's disease and predominantly visual complaints. RESULTS: Eight patients with the visual variant of Alzheimer's disease were reviewed. All had seen eye care providers before referral to the neuro-ophthalmology clinic for visual complaints but without a diagnosis. Four patients had homonymous visual field loss, and two had presumed cortical visual impairment. Neuroimaging showed either normal brain (1 patient) or atrophy of the parietal or occipital areas but no structural lesions (7 patients). Fluoro-18-deoxyglucose positron emission tomography scans were performed in five of the cases, and all showed hypoperfusion in the parietooccipital areas. Neuropsychologic testing revealed visuospatial deficits in all 5 patients tested. CONCLUSIONS: Visual symptoms might be the presenting (or rarely only) manifestation of Alzheimer's disease. Clinicians should be aware of the visual variant of Alzheimer's disease. Neuropsychological testing and magnetic resonance imaging (MRI) provide supporting evidence for the diagnosis. Positron emission tomography scans might be helpful in selected cases, especially those with a normal MRI. |
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Authors:
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Andrew G Lee; Coleman O Martin |
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Publication Detail:
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Type: Case Reports; Journal Article |
Journal Detail:
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Title: Ophthalmology Volume: 111 ISSN: 0161-6420 ISO Abbreviation: Ophthalmology Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-03-15 Completed Date: 2004-03-23 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7802443 Medline TA: Ophthalmology Country: United States |
Other Details:
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Languages: eng Pagination: 376-80; discussion 380-1 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Iowa Hospitals and Clinics, Iowa City, Iowa 52242, USA. andrew-lee@uiowa.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Alzheimer Disease / diagnosis* Atrophy Blindness, Cortical / diagnosis Female Fluorodeoxyglucose F18 / diagnostic use Hemianopsia / diagnosis Humans Magnetic Resonance Imaging Male Middle Aged Neuropsychological Tests Occipital Lobe / pathology Parietal Lobe / pathology Perimetry Retrospective Studies Tomography, Emission-Computed Vision Disorders / diagnosis* Visual Fields* |
| Chemical | |
Reg. No./Substance:
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63503-12-8/Fluorodeoxyglucose F18 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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