| Neuro-ophthalmic complications in giant cell arteritis. | |
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MedLine Citation:
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PMID: 18606086 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Giant cell arteritis (GCA) is a medical emergency characterized by systemic inflammation and critical ischemia. Neuro-ophthalmic complications occur early, with permanent vision loss in up to one fifth of patients. This mainly results from failure of prompt recognition and treatment. Diagnosis of GCA is often preceded by unrecognized symptoms, including constitutional upset and jaw claudication. Features predictive of permanent visual loss include jaw claudication and temporal artery abnormalities on physical examination. These patients often do not mount high inflammatory responses. Modern imaging techniques show diagnostic promise, and have led to an increased recognition of major artery involvement in GCA. However, temporal artery biopsy remains the gold standard for investigation. Intimal hyperplasia on histologic examination is associated with neuro-ophthalmic complications. The mainstay of therapy remains corticosteroids. Experience using conventional disease-modifying drugs has been mixed, and biologic therapies require further evaluation for their steroid-sparing potential. |
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Authors:
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Frances A Borg; Victoria L J Salter; Bhaskar Dasgupta |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Current allergy and asthma reports Volume: 8 ISSN: 1534-6315 ISO Abbreviation: Curr Allergy Asthma Rep Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-08 Completed Date: 2008-08-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101096440 Medline TA: Curr Allergy Asthma Rep Country: United States |
Other Details:
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Languages: eng Pagination: 323-30 Citation Subset: IM |
Affiliation:
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Department of Rheumatology, Southend University Hospital, Prittlewell Chase, Westcliffe-on-Sea, Essex, SS0 0RY, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Cortex Hormones
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therapeutic use* Anti-Inflammatory Agents / therapeutic use* Aspirin / therapeutic use Cytokines / immunology, metabolism* Giant Cell Arteritis / complications*, diagnosis, drug therapy, immunology Humans Ischemia / immunology, physiopathology Risk Factors T-Lymphocytes / immunology, metabolism Vision Disorders / etiology*, immunology, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Adrenal Cortex Hormones; 0/Anti-Inflammatory Agents; 0/Cytokines; 50-78-2/Aspirin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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