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Neuro-oncology: Five new things.
MedLine Citation:
PMID:  24195021     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Recent reports herald important advances in our understanding and management of gliomas. A role for alkylator chemotherapy in the management of certain high-grade gliomas has been confirmed and linked to specific, clinically ascertainable molecular markers. Magnetic resonance spectroscopy can now image 2-hydroxyglutarate, an oncometabolite restricted to the three-quarters of low-intermediate grade gliomas harboring an isocitrate dehydrogenase gene mutation; this has powerful implications for diagnosis and assessment of response to therapies. Genome-wide association studies point to several SNPs conveying increased risk of glioma; further studies of the involved genes and RNA products will enhance our understanding of glioma development. Finally, high-throughput sequencing has identified novel mutations in a histone-coding gene and in genes related to the histone complex in pediatric glioblastoma.
Authors:
David Schiff; Benjamin Purow
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Neurology. Clinical practice     Volume:  3     ISSN:  2163-0402     ISO Abbreviation:  Neurol Clin Pract     Publication Date:  2013 Aug 
Date Detail:
Created Date:  2013-11-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101577149     Medline TA:  Neurol Clin Pract     Country:  -    
Other Details:
Languages:  ENG     Pagination:  326-333     Citation Subset:  -    
Affiliation:
Departments of Neurology and Neuroscience, University of Virginia School of Medicine, Charlottesville.
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