| Neuro-glio-vascular Interaction in Ischemic Brains. | |
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MedLine Citation:
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PMID: 21467793 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The brain contains glial cells (astrocytes, microglia, and oligodendrocytes) and endothelial cells in addition to neurons. Under various pathologic conditions, the invasion of leukocytes such as neutrophils, monocytes/macrophages, and lymphocytes is observed. Interactions among these cell types play crucial roles both in brain function and dysfunction. However, the molecular basis of such interactions remains unclear. Cytokines and chemokines were originally identified as essential mediators of inflammatory and immune responses. Enhanced production and release of cytokines/chemokines are observed also in the central nervous system under various pathologic conditions. There is growing evidence showing that brain cytokines/chemokines play crucial roles in the neuro-glio-vascular interaction underlying the pathology of various brain disorders and therefore are potential targets for the development of novel and effective therapeutics for central nervous system diseases. This article reviews the evidence for the involvement of cytokines/chemokines in ischemic brain injury and presents our data on introducing organotypic brain slice cultures and in vitro blood brain barrier models as useful tools to investigate neuro-glio-vascular interaction. |
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Authors:
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Masabumi Minami |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan Volume: 131 ISSN: 0031-6903 ISO Abbreviation: Yakugaku Zasshi Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-04-06 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0413613 Medline TA: Yakugaku Zasshi Country: Japan |
Other Details:
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Languages: eng Pagination: 539-44 Citation Subset: IM |
Affiliation:
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Department of Pharmacology, Graduate School of Pharmaceutical Sciences, Hokkaido University. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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