| Neuro-QOL: brief measures of health-related quality of life for clinical research in neurology. | |
| | |
MedLine Citation:
|
PMID: 22573626 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To address the need for brief, reliable, valid, and standardized quality of life (QOL) assessment applicable across neurologic conditions. METHODS: Drawing from larger calibrated item banks, we developed short measures (8-9 items each) of 13 different QOL domains across physical, mental, and social health and evaluated their validity and reliability. Three samples were utilized during short form development: general population (Internet-based, n = 2,113); clinical panel (Internet-based, n = 553); and clinical outpatient (clinic-based, n = 581). All short forms are expressed as T scores with a mean of 50 and SD of 10. RESULTS: Internal consistency (Cronbach α) of the 13 short forms ranged from 0.85 to 0.97. Correlations between short form and full-length item bank scores ranged from 0.88 to 0.99 (0.82-0.96 after removing common items from banks). Online respondents were asked whether they had any of 19 different chronic health conditions, and whether or not those reported conditions interfered with ability to function normally. All short forms, across physical, mental, and social health, were able to separate people who reported no health condition from those who reported 1-2 or 3 or more. In addition, scores on all 13 domains were worse for people who acknowledged being limited by the health conditions they reported, compared to those who reported conditions but were not limited by them. CONCLUSION: These 13 brief measures of self-reported QOL are reliable and show preliminary evidence of concurrent validity inasmuch as they differentiate people based upon number of reported health conditions and whether those reported conditions impede normal function. |
| | |
Authors:
|
D Cella; J-S Lai; C J Nowinski; D Victorson; A Peterman; D Miller; F Bethoux; A Heinemann; S Rubin; J E Cavazos; A T Reder; R Sufit; T Simuni; G L Holmes; A Siderowf; V Wojna; R Bode; N McKinney; T Podrabsky; K Wortman; S Choi; R Gershon; N Rothrock; C Moy |
Related Documents
:
|
19835056 - Welfare assessment and phenotype characterisation of transgenic mice. 22497586 - Extending the paramedic role in rural australia: a story of flexibility and innovation. 22304506 - Seeking better health care outcomes: the ethics of using the "nudge". 22515866 - "here man learns about himself": visual education and the rise and fall of the american... 12061516 - Developing policies responsive to barriers to health care among rural residents: what d... 9384696 - Multiple involvement of nucleotide excision repair enzymes: clinical manifestations of ... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural Date: 2012-05-09 |
Journal Detail:
|
Title: Neurology Volume: 78 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2012 Jun |
Date Detail:
|
Created Date: 2012-06-05 Completed Date: 2012-08-09 Revised Date: 2013-04-16 |
Medline Journal Info:
|
Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
|
Languages: eng Pagination: 1860-7 Citation Subset: AIM; IM |
Affiliation:
|
Northwestern University Feinberg School of Medicine, Chicago, IL, USA. d-cella@northwestern.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Female Health Status* Humans Internet / utilization Male Middle Aged Nervous System Diseases / psychology* Neurology / instrumentation*, methods Outpatients / psychology Quality of Life* Questionnaires / standards* Reproducibility of Results Self Report |
| Grant Support | |
ID/Acronym/Agency:
|
HHSN265200423601C//PHS HHS |
| Comments/Corrections | |
Comment In:
|
Neurology. 2012 Jun 5;78(23):1813-4
[PMID:
22573624
]
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The elusive biomarker for personalized medicine in multiple sclerosis: The search continues.
Next Document: Placebo-controlled trial of lubiprostone for constipation associated with Parkinson disease.