| Neuritogenic Lewis rat T cells use Tcrb chains that include a new Tcrb-V8 family member. | |
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MedLine Citation:
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PMID: 7521858 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The P2 protein obtained from Schwann cells induces a population of T cells which, upon adoptive transfer, causes the disease experimental allergic neuritis (EAN), an animal model for Guillain-Barre syndrome. In this report, a truncated peptide, FR22, derived from a previously reported neuritogenic T-cell determinant, was used to generate from Lewis rats T cells that were shown to cause EAN. Since our previous studies showed that Tcrb-V8 was used by a majority of T-cell hybridomas specific for the neuritogenic peptide P26, which contains the FR22 sequence, we sequenced the Tcrb-V8+ mRNA from FR22-specific T-cell lines, and compared the sequences obtained with those obtained from similarly generated myelin basic protein (MBP) 68-88-specific Lewis rat T-cell lines. We found that in the EAN lines, several members of the Tcrb-V8 family were used, including a new family member, Tcrb-V8E. This was more diverse than the MBP-68-88-specific response in which only a single Tcrb-V8 family member was used. Also, in the EAN lines, the beta chain sequences did not show the same conserved junctional regions seen in the MBP lines. Thus, T-cell receptor beta chain usage in the response to this dominant neuritogenic peptide appears to be less restricted than the response to the dominant encephalitogenic determinant of MBP both in V region usage and in CDR3 usage. |
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Authors:
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X M Zhang; T R Esch; L Clark; S Gregorian; A Rostami; L Otvos; E Heber-Katz |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Immunogenetics Volume: 40 ISSN: 0093-7711 ISO Abbreviation: Immunogenetics Publication Date: 1994 |
Date Detail:
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Created Date: 1994-10-12 Completed Date: 1994-10-12 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0420404 Medline TA: Immunogenetics Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 266-70 Citation Subset: IM |
Affiliation:
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Wistar Institute, Philadelphia, PA 19104. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/U06100; U06101; U06102; U06103; U06104 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acid Sequence Animals Base Sequence Female Genes Molecular Sequence Data Myelin Basic Proteins / immunology* Myelin P2 Protein* Neurites Neuritis, Autoimmune, Experimental / immunology* Peptide Fragments / immunology* Peptides / chemistry, immunology Rats Rats, Inbred Lew Receptors, Antigen, T-Cell, alpha-beta / genetics* Sequence Alignment Sequence Homology, Nucleic Acid |
| Grant Support | |
ID/Acronym/Agency:
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AR39489/AR/NIAMS NIH HHS; NS08075/NS/NINDS NIH HHS; NS11036/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Myelin Basic Proteins; 0/Myelin P2 Protein; 0/Peptide Fragments; 0/Peptides; 0/Receptors, Antigen, T-Cell, alpha-beta; 0/myelin P2 peptide SP26 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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