| Neuritic plaques in Alzheimer disease originate from neurofibrillary tangles. | |
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MedLine Citation:
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PMID: 8321160 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Amyloid beta-protein is a major focus in efforts to understand the etiology of Alzheimer disease yet there is little known about the mechanism of its deposition in plaques. I propose deposition of amyloid in neuritic plaques depends on the remains of neurofibrillary tangles after neuronal death. The interaction of these two lesions means neuritic plaques are not only dependent on neurofibrillary tangles and neuronal death but also dependent on their concurrence. |
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Authors:
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G Perry |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Medical hypotheses Volume: 40 ISSN: 0306-9877 ISO Abbreviation: Med. Hypotheses Publication Date: 1993 Apr |
Date Detail:
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Created Date: 1993-08-03 Completed Date: 1993-08-03 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7505668 Medline TA: Med Hypotheses Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 257-8 Citation Subset: IM |
Affiliation:
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Division of Neuropathology, Case Western Reserve University, Cleveland, Ohio 44106-4901. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Alzheimer Disease
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pathology* Amyloid beta-Protein / metabolism Brain / pathology* Humans Models, Biological Neurites / ultrastructure* Neurofibrillary Tangles / pathology* |
| Chemical | |
Reg. No./Substance:
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0/Amyloid beta-Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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