Document Detail

Neuregulin in heart failure : reverse translation from cancer cardiotoxicity to new heart failure therapy.
MedLine Citation:
PMID:  21633805     Owner:  NLM     Status:  MEDLINE    
Trastuzumab is a monoclonal antibody to the ErbB2 (Her2nue) receptor over-expressed in Her2(+) breast cancer. Trastuzumab-related cardiotoxicity has revealed the importance of ErbB2 signaling in the heart. Neuregulin (NRG-1) is an important stress-mediated paracrine growth factor that signals through the family of ErbB receptors to promote cardioprotection (myocyte cell survival, proliferation, differentiation, hypertrophy, and angiogenesis). Animal models with disrupted NRG/ErbB signaling fail to develop normally or result in impaired cardiac function post-natally. Pre-clinical animal studies and early-phase human studies suggest that recombinant NRG-1 holds promise as a new therapy for the treatment of various forms of heart failure. Much work is needed to further understand the exact mechanisms of cardiac repair and to find a safe mode of application for recombinant NRG-1 in heart failure.
C A Geisberg; D J Lenihan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Herz     Volume:  36     ISSN:  1615-6692     ISO Abbreviation:  Herz     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-16     Completed Date:  2012-03-15     Revised Date:  2013-05-08    
Medline Journal Info:
Nlm Unique ID:  7801231     Medline TA:  Herz     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  306-10     Citation Subset:  IM    
Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, USA.
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MeSH Terms
Antibodies, Monoclonal / therapeutic use*
Antibodies, Monoclonal, Humanized / adverse effects*
Antineoplastic Agents / adverse effects
Cardiotoxins / adverse effects*
Heart Failure / metabolism*,  prevention & control*
Neuregulin-1 / metabolism*
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antibodies, Monoclonal, Humanized; 0/Antineoplastic Agents; 0/Cardiotoxins; 0/Neuregulin-1; P188ANX8CK/trastuzumab

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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