Document Detail


Neuregulin in heart failure : reverse translation from cancer cardiotoxicity to new heart failure therapy.
MedLine Citation:
PMID:  21633805     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Trastuzumab is a monoclonal antibody to the ErbB2 (Her2nue) receptor over-expressed in Her2(+) breast cancer. Trastuzumab-related cardiotoxicity has revealed the importance of ErbB2 signaling in the heart. Neuregulin (NRG-1) is an important stress-mediated paracrine growth factor that signals through the family of ErbB receptors to promote cardioprotection (myocyte cell survival, proliferation, differentiation, hypertrophy, and angiogenesis). Animal models with disrupted NRG/ErbB signaling fail to develop normally or result in impaired cardiac function post-natally. Pre-clinical animal studies and early-phase human studies suggest that recombinant NRG-1 holds promise as a new therapy for the treatment of various forms of heart failure. Much work is needed to further understand the exact mechanisms of cardiac repair and to find a safe mode of application for recombinant NRG-1 in heart failure.
Authors:
C A Geisberg; D J Lenihan
Related Documents :
4049275 - Evaluation of bendectin embryotoxicity in nonhuman primates: i. ventricular septal defe...
9240885 - Clinical and echocardiographic evaluation of neonates with heart murmurs.
834465 - Atrio-ventricular conduction defects and arrhythmias by selective perfusion of the a-v ...
12963235 - Aorto-right atrial fistula.
8879945 - Pathophysiology and initial management of the acute coronary syndromes.
6713625 - Trace elements in serum from pakistani patients with acute and chronic ischemic heart d...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Herz     Volume:  36     ISSN:  1615-6692     ISO Abbreviation:  Herz     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-16     Completed Date:  2012-03-15     Revised Date:  2013-05-08    
Medline Journal Info:
Nlm Unique ID:  7801231     Medline TA:  Herz     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  306-10     Citation Subset:  IM    
Affiliation:
Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, USA. carrie.geisberg@vanderbilt.edu
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Antibodies, Monoclonal / therapeutic use*
Antibodies, Monoclonal, Humanized / adverse effects*
Antineoplastic Agents / adverse effects
Cardiotoxins / adverse effects*
Heart Failure / metabolism*,  prevention & control*
Humans
Neuregulin-1 / metabolism*
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Antibodies, Monoclonal, Humanized; 0/Antineoplastic Agents; 0/Cardiotoxins; 0/Neuregulin-1; P188ANX8CK/trastuzumab

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Acute Wilson disease.
Next Document:  Cardiac side effects of conventional and particle radiotherapy in cancer patients.