Document Detail


Neuregulin-1 (Nrg1) is mainly expressed in rat pituitary gonadotroph cells and possibly regulates prolactin (PRL) secretion in a juxtacrine manner.
MedLine Citation:
PMID:  21919974     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The binding of Neuregulin-1 (Nrg1) to its cognate receptors ErbB-3 and -4 mediates intercellular and intracellular communication. In vitro, this interaction has been shown to control prolactin (PRL) secretion from pituitary tumour cells. However, Nrg1/ErbB signaling and its function in vivo are not well understood. In this study, we demonstrated that type I and III Nrg1 isoforms were expressed in the rat anterior pituitary. We observed that Nrg1 positive gonadotrophs can form contacts with lactotrophs, which are positive for ErbB-3 receptor. In addition, we show that gonadotroph cell-derived Nrg1 regulates the secretion of an 18 kDa form of PRL from pituitary lactosomatotroph GH3 cells in vitro. Our results strongly argue that gonadotrophs are the major source of Nrg1 in the normal anterior pituitary and that Nrg1 may function as a paracrine/juxtacrine regulator of PRL secretion.
Authors:
Weijiang Zhao; Song-Guang Ren
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-9-15
Journal Detail:
Title:  Journal of neuroendocrinology     Volume:  -     ISSN:  1365-2826     ISO Abbreviation:  -     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-9-16     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913461     Medline TA:  J Neuroendocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Journal of Neuroendocrinology © 2011 Blackwell Publishing.
Affiliation:
Shantou University Medical College, Center for NeuroscienceCedars-Sinai Medical Center, Department of Medicine.
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