| Neuraminidase Inhibitors from Marine-derived Actinomycete Streptomyces seoulensis. | |
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MedLine Citation:
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PMID: 23311635 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIMS: This work was performed to characterize new secondary metabolites with neuraminidase inhibitory activity from marine actinomycete strains. METHODS AND RESULTS: An actinomycete strain IFB-A01, capable of producing new neuraminidase inhibitors, was isolated from the gut of shrimp Penasus orientalis and identified as Streptomyces seoulensis according to its 16S rRNA sequence (over 99% homology with that of the standard strain). Repeated chromatography of the methanol extract of the solid-substrate culture of S. seoulensis IFB-A01 led to the isolation of streptoseolactone (1), and limazepines G (2) and H (3). The structures of 1-3 were determined by a combination of IR, ESI-MS, 1D ((1) H and (13) C NMR, and DEPT) and 2D NMR experiments (HMQC, HMBC, (1) H-(1) H COSY and NOESY). Compounds 1-3 showed significant inhibition on neuraminidase in a dose dependent manner with IC(50) values of 3.92, 7.50 and 7.37 μM, respectively. CONCLUSIONS: This is the first report of two new (1 and 2) and known (3, recovered as a natural product for the first time in the work) neuraminidase inhibitors from the marine-derived actinomycete S. seoulensis IFB-A01. © 2013 Institute of Functional Biomolecules. |
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Authors:
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Rui Hua Jiao; Hao Xu; Jiang Tao Cui; Hui Ming Ge; Ren Xiang Tan |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-13 |
Journal Detail:
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Title: Journal of applied microbiology Volume: - ISSN: 1365-2672 ISO Abbreviation: J. Appl. Microbiol. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-14 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9706280 Medline TA: J Appl Microbiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2013 Institute of Functional Biomolecules. |
Affiliation:
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Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093, P. R. China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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