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Neuraminidase Inhibitors from Marine-derived Actinomycete Streptomyces seoulensis.
MedLine Citation:
PMID:  23311635     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIMS: This work was performed to characterize new secondary metabolites with neuraminidase inhibitory activity from marine actinomycete strains. METHODS AND RESULTS: An actinomycete strain IFB-A01, capable of producing new neuraminidase inhibitors, was isolated from the gut of shrimp Penasus orientalis and identified as Streptomyces seoulensis according to its 16S rRNA sequence (over 99% homology with that of the standard strain). Repeated chromatography of the methanol extract of the solid-substrate culture of S. seoulensis IFB-A01 led to the isolation of streptoseolactone (1), and limazepines G (2) and H (3). The structures of 1-3 were determined by a combination of IR, ESI-MS, 1D ((1) H and (13) C NMR, and DEPT) and 2D NMR experiments (HMQC, HMBC, (1) H-(1) H COSY and NOESY). Compounds 1-3 showed significant inhibition on neuraminidase in a dose dependent manner with IC(50) values of 3.92, 7.50 and 7.37 μM, respectively. CONCLUSIONS: This is the first report of two new (1 and 2) and known (3, recovered as a natural product for the first time in the work) neuraminidase inhibitors from the marine-derived actinomycete S. seoulensis IFB-A01. © 2013 Institute of Functional Biomolecules.
Authors:
Rui Hua Jiao; Hao Xu; Jiang Tao Cui; Hui Ming Ge; Ren Xiang Tan
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-13
Journal Detail:
Title:  Journal of applied microbiology     Volume:  -     ISSN:  1365-2672     ISO Abbreviation:  J. Appl. Microbiol.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9706280     Medline TA:  J Appl Microbiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 Institute of Functional Biomolecules.
Affiliation:
Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, 210093, P. R. China.
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