Document Detail


Neural tube defects and serum zinc.
MedLine Citation:
PMID:  8399013     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: To investigate the relationship of zinc in the causation of neural tube defects and so explore the possible role as a cause of these defects. DESIGN: Stored serum samples collected as part of the Medical Research Council's multicentre randomised trial section of vitamin supplementation in the prevention of neural tube defects were retrieved in respect of women who had had an affected pregnancy together with four matched unaffected controls per case. One control was selected from each of the four randomisation groups: 1. no extra vitamins; 2. folic acid supplementation alone; 3. folic acid and other vitamin supplementation; and 4. other vitamin supplementation, such that it was matched with an NTD case by study centre, maternal age (the year of birth differed at most by one year) and duration of storage of the serum sample (in most instances to within the same year). SETTING: A prospective case-control study using serum samples stored at -40 degrees C. The serum samples were collected from women at entry to the trial, immediately before the women became pregnant and at about 12 weeks of pregnancy. SUBJECTS: Twenty-seven women with a pregnancy associated with a neural tube defect and 108 matched controls with unaffected pregnancies. RESULTS: There was no association between serum zinc levels and neural tube defects; the mean values in microgram/dl were: 82 and 85 in cases and controls, respectively, at entry to the study; 86 and 87 micrograms/dl just before pregnancy; and 76 and 80 micrograms/dl in the first trimester of pregnancy. Folic acid supplementation did not have an effect on serum zinc levels. CONCLUSION: Within the range of serum zinc levels observed among women in our study, serum zinc is not a cause of neural tube defects, and periconceptional folic acid supplements do not compromise the zinc status of the mother or the embryo with respect to zinc intake.
Authors:
M Hambidge; A Hackshaw; N Wald
Related Documents :
4026363 - Maternal serum folate and vitamin b12 concentrations in pregnancies associated with neu...
12745973 - Effects of heat on embryos and foetuses.
24684703 - Influence of maternal body mass index on accuracy and reliability of external fetal mon...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  British journal of obstetrics and gynaecology     Volume:  100     ISSN:  0306-5456     ISO Abbreviation:  Br J Obstet Gynaecol     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-11-01     Completed Date:  1993-11-01     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7503752     Medline TA:  Br J Obstet Gynaecol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  746-9     Citation Subset:  AIM; IM    
Affiliation:
Department of Paediatrics, University of Colorado Health Services Centre, Denver.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Case-Control Studies
Female
Folic Acid / administration & dosage
Humans
Neural Tube Defects / blood*,  etiology
Pregnancy
Prospective Studies
Zinc / blood*,  deficiency
Grant Support
ID/Acronym/Agency:
NIDDKD R01DK12432/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
59-30-3/Folic Acid; 7440-66-6/Zinc

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Prediction of morbidity in small and normally grown fetuses by fetal heart rate variability, biophys...
Next Document:  Denervation and re-innervation of the urethral sphincter in the aetiology of genuine stress incontin...