Document Detail

Neural tube defects in the offspring of thalassemia carriers.
MedLine Citation:
PMID:  12566767     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The risk of neural tube defects (NTDs) is negatively correlated with maternal folate levels in early pregnancy. Thalassemia carriers often have reduced red cell folate contents. The aim of this study was to verify whether thalassemia carriers are at increased risk of having offspring with a NTD. METHODS: We retrospectively evaluated the prevalence of thalassemia carriers among 75 women who had prenatal diagnoses of NTDs made at our center. RESULTS: The prevalence of beta-thalassemia carriers among the affected pregnancies was significantly higher than in the general population (22.5 versus 14%, p < 0.05, chi(2) test). CONCLUSION: Although inconclusive, these data indicate that folate supplementation is mandatory among women with thalassemia who are planning a pregnancy.
Rosa Maria Ibba; Maria Angelica Zoppi; Marcella Floris; Fabiola Manca; Carolina Axiana; Antonio Cao; Giovanni Monni
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  18     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:    2003 Jan-Feb
Date Detail:
Created Date:  2003-02-04     Completed Date:  2003-09-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  5-7     Citation Subset:  IM    
Copyright Information:
Copyright 2003 S. Karger AG, Basel
Department of Obstetrics and Gynecology, Prenatal and Preimplantation Diagnosis and Fetal Therapy, Regional Hospital for Microcythemia, Cagliari, Italy.
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MeSH Terms
Italy / epidemiology
Neural Tube Defects / epidemiology*
Pregnancy Complications / epidemiology*
Retrospective Studies
beta-Thalassemia / epidemiology*

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