Document Detail

Neural tube defects in Wales: changing demographics from 1998 to 2009.
MedLine Citation:
PMID:  22149474     Owner:  NLM     Status:  Publisher    
Objective. To establish if there is evidence for the perceived increase in the number of live births with a Neural tube defect (NTD) in South Wales from 1998 to 2009. Methods. Data was obtained from the Congenital Abnormalities Register Information Services (CARIS), which recorded 305 cases of pregnancies involving neural tube defects. Descriptive analysis was carried out for each year in this period to obtain the number of live births, the proportion of live births compared to NTD pregnancies, plus the number and the percentage terminated each year. Results. From the 305 cases, 66 resulted in live births, 230 in terminations. There was an increase in live births from 13.8% in 1998 to 33.3% in 2009, and a decrease in terminations from 82.76% in 1998 to 62.50% in 2009. The data also showed that this increase occurred mainly in the South of Wales. Discussion. Over this time period, there has been a decrease in the number of pregnancies affected by a neural tube defect and a decline in the proportion of pregnancies with neural tube defects resulting in terminations. Consequently, there has been an increase in the number of live births. The reasons for this change in trend is unclear, it may be that prospective parents are more willing to proceed with the pregnancy due to better support and services and the improved prognosis for children with neural tube defects. Conclusion. This data clearly shows that the number of children born with a NTD is increasing, and if this trend persists, services will have to expand and adapt to the change in the demographic of this population.
Philippa Czapran; Frances Gibbon; Bryan Beattie; Nicholas Wilson-Jones; Paul Leach
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-12-9
Journal Detail:
Title:  British journal of neurosurgery     Volume:  -     ISSN:  1360-046X     ISO Abbreviation:  -     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8800054     Medline TA:  Br J Neurosurg     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
University of Wales College of Medicine , Cardiff , UK.
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