Document Detail


Neural syntax: cell assemblies, synapsembles, and readers.
MedLine Citation:
PMID:  21040841     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A widely discussed hypothesis in neuroscience is that transiently active ensembles of neurons, known as "cell assemblies," underlie numerous operations of the brain, from encoding memories to reasoning. However, the mechanisms responsible for the formation and disbanding of cell assemblies and temporal evolution of cell assembly sequences are not well understood. I introduce and review three interconnected topics, which could facilitate progress in defining cell assemblies, identifying their neuronal organization, and revealing causal relationships between assembly organization and behavior. First, I hypothesize that cell assemblies are best understood in light of their output product, as detected by "reader-actuator" mechanisms. Second, I suggest that the hierarchical organization of cell assemblies may be regarded as a neural syntax. Third, constituents of the neural syntax are linked together by dynamically changing constellations of synaptic weights ("synapsembles"). The existing support for this tripartite framework is reviewed and strategies for experimental testing of its predictions are discussed.
Authors:
György Buzsáki
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review    
Journal Detail:
Title:  Neuron     Volume:  68     ISSN:  1097-4199     ISO Abbreviation:  Neuron     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-02     Completed Date:  2010-12-07     Revised Date:  2014-08-08    
Medline Journal Info:
Nlm Unique ID:  8809320     Medline TA:  Neuron     Country:  United States    
Other Details:
Languages:  eng     Pagination:  362-85     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / physiology
Electrophysiology
Humans
Models, Neurological
Neural Pathways / physiology*
Neurons / physiology*
Synapses / physiology*
Grant Support
ID/Acronym/Agency:
MH54671/MH/NIMH NIH HHS; NS034994/NS/NINDS NIH HHS; R01 DC009947-04/DC/NIDCD NIH HHS; R01 DC009947-05/DC/NIDCD NIH HHS; R01 MH054671/MH/NIMH NIH HHS; R01 MH054671-12/MH/NIMH NIH HHS; R01 MH054671-13/MH/NIMH NIH HHS; R01 NS034994-13/NS/NINDS NIH HHS; R01 NS034994-14/NS/NINDS NIH HHS
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