Document Detail

Neural stem cells reduce brain injury after unilateral carotid ligation.
MedLine Citation:
PMID:  18206788     Owner:  NLM     Status:  MEDLINE    
Neonatal stroke presents with seizures and results in neurologic morbidity, including epilepsy, hemiparesis, and cognitive deficits. Stem cell-based therapy offers a possible therapeutic strategy for neonatal stroke. We developed an immature mouse model of stroke with acute seizures and ischemic brain injury. Postnatal day 12 CD1 mice received right-sided carotid ligation. Two or 7 days after ligation, mice received an intrastriatal injection of B5 embryonic stem cell-derived neural stem cells. Four weeks after ligation, hemispheric brain atrophy was measured. Pups receiving stem cells 2 days after ligation had less severe hemispheric brain atrophy compared with either noninjected or vehicle-injected ligated controls. Transplanted cells survived, but 3 out of 10 pups injected with stem cells developed local tumors. No difference in hemispheric brain atrophy was seen in mice injected with stem cells 7 days after ligation. Neural stem cells have the potential to ameliorate ischemic injury in the immature brain, although tumor development is a serious concern.
Anne M Comi; Eunpi Cho; Justin D Mulholland; Andrew Hooper; Qun Li; Yun Qu; Devin S Gary; John W McDonald; Michael V Johnston
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric neurology     Volume:  38     ISSN:  0887-8994     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-01-21     Completed Date:  2008-03-11     Revised Date:  2014-09-20    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  86-92     Citation Subset:  IM    
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MeSH Terms
Brain Ischemia / etiology,  mortality,  therapy*
Brain Neoplasms / pathology
Carotid Arteries / physiology*
Cell Survival
Neurons / drug effects,  transplantation*
Seizures / etiology
Stem Cell Transplantation* / adverse effects
Stem Cells / drug effects
Stereotaxic Techniques
Stroke / etiology,  mortality,  therapy*
Teratoma / pathology
Tretinoin / pharmacology
Grant Support
Reg. No./Substance:

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