| Neural stem cell engineering: directed differentiation of adult and embryonic stem cells into neurons. | |
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MedLine Citation:
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PMID: 17981526 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Both adult neural stem cells and embryonic stem cells have shown the capacity to differentiation into multiple cell types of the adult nervous system. They will therefore serve as valuable systems for basic investigations of cell fate choice mechanisms, as well as play important future roles in applications ranging from regenerative medicine to drug screening. However, there are significant challenges remaining, including the identification of signaling factors that specify cell fate in the stem cell niche, the analysis of intracellular targets and mechanisms of these extracellular signals, and the development of ex vivo culture systems that can exert efficient control over cell function. This review will discuss progress in the identification of signaling mechanisms and culture systems that regulate neural differentiation, neuronal differentiation, and neuronal subtype specification. |
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Authors:
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Matthew J Robertson; Phung Gip; David V Schaffer |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review Date: 2008-01-01 |
Journal Detail:
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Title: Frontiers in bioscience : a journal and virtual library Volume: 13 ISSN: 1093-4715 ISO Abbreviation: Front. Biosci. Publication Date: 2008 |
Date Detail:
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Created Date: 2007-11-05 Completed Date: 2007-12-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9709506 Medline TA: Front Biosci Country: United States |
Other Details:
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Languages: eng Pagination: 21-50 Citation Subset: IM |
Affiliation:
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Department of Chemical Engineering and The Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Culture Techniques / methods* Cell Differentiation Cell Transplantation Embryonic Stem Cells / cytology* Hippocampus / cytology Humans Models, Biological Motor Neurons / metabolism Neurons / metabolism* Phenotype Stem Cells / cytology* |
| Grant Support | |
ID/Acronym/Agency:
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T32 GM007352/GM/NIGMS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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