| Neural responses to antigenic challenges and immunomodulatory factors. | |
| | |
| Jump to Full Text | |
MedLine Citation:
|
PMID: 2399739 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
In studies designed to examine the effects of the immune system, recordings of multi-unit electrical activity (MUA) in the central nervous system were made in the preoptic area/anterior hypothalamus (POA/AH) and paraventricular nucleus (PVN) of rats, following sheep red blood cell (SRBC) immunization. Peak increases in POA/AH MUA were observed on the fifth day following SRBC sensitization, the day on which serum antibodies were first detected. A significant increase in paraventricular nucleus (PVN) MUA was also observed on the sixth day. These changes in POA/AH and PVN MUA were found to be associated with increased plasma corticosterone levels on day 8. Induction of a second immune response to SRBC evoked a POA/AH MUA increase of extended duration but reduced amplitude, while administration of the immunosuppressive drug, cyclophosphamide, prevented both antibody generation and any increases in POA/AH MUA. These data suggest that activation of the immune system may provide signals, in the form of chemical messengers, which are able to alter neural activity in some regions of the brain that are important in neuroendocrine regulatory mechanisms. Accordingly, intracerebroventricular injections of thymic humoral factor or alpha-interferon decreased POA/AH MUA, increased EEG synchronization, and decreased plasma levels of corticosterone. Histamine and interleukin 1 did not alter POA/AH MUA but decreased EEG synchronization and increased plasma levels of corticosterone. |
| | |
Authors:
|
D Saphier; H Ovadia; O Abramsky |
Related Documents
:
|
391699 - Specific suppression of delayed hypersensitivity response to sheep erythrocytes by hete... 5534449 - Surface antigens of immunocompetent cells. i. effect of theta and pc.1 alloantisera on ... 3047539 - Modulating action of escherichia coli heat-stable enterotoxin (sta) on the humoral immu... 1083659 - Interference with antibody-feedback by irradiation, thymus cells, the allogeneic effect... 2235829 - Immune responsiveness of neonatal chicks and immunocyte precursors from unprimed juveni... 1991819 - Suppression of immune responses to acetylcholine receptor by interleukin 2-fusion toxin... 9152039 - Widely used, commercially available chlamydia pneumoniae antigen contaminated with myco... 7229659 - Experimental allergic encephalomyelitis. characterization of serum factors causing demy... 8739349 - Cultivation of mouse-mouse hybridomas producing igm monoclonal antibodies. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: The Yale journal of biology and medicine Volume: 63 ISSN: 0044-0086 ISO Abbreviation: Yale J Biol Med Publication Date: 1990 Mar-Apr |
Date Detail:
|
Created Date: 1990-10-16 Completed Date: 1990-10-16 Revised Date: 2009-11-18 |
Medline Journal Info:
|
Nlm Unique ID: 0417414 Medline TA: Yale J Biol Med Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 109-19 Citation Subset: IM |
Affiliation:
|
Department of Neurology, Hadassah University Hospital, Jerusalem, Israel. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Antigens / immunology* Corticosterone / blood Cyclophosphamide / pharmacology Electroencephalography Erythrocytes / immunology Feedback Histamine / pharmacology Hypothalamus / physiology* Interferon Type I / pharmacology Interleukin-1 / pharmacology Male Neuroimmunomodulation* Paraventricular Hypothalamic Nucleus / physiology Preoptic Area / physiology Rats Thymus Hormones / pharmacology |
| Chemical | |
Reg. No./Substance:
|
0/Antigens; 0/Interferon Type I; 0/Interleukin-1; 0/Thymus Hormones; 50-18-0/Cyclophosphamide; 50-22-6/Corticosterone; 51-45-6/Histamine; 63340-72-7/thymic humoral factor |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
| Full Text | |
|
Journal Information Journal ID (nlm-ta): Yale J Biol Med Journal ID (pmc): yjbm ISSN: 0044-0086 ISSN: 1551-4056 Publisher: Yale Journal of Biology and Medicine |
Article Information Download PDF  Print publication date: Season: Mar?Apr Year: 1990 Volume: 63 Issue: 2 First Page: 109 Last Page: 119 ID: 2589313 PubMed Id: 2399739 |
| Neural responses to antigenic challenges and immunomodulatory factors. | |
| D. Saphier | |
| H. Ovadia | |
| O. Abramsky | |
| Department of Neurology, Hadassah University Hospital, Jerusalem, Israel. |
|
Article Categories:
|
|
Previous Document: Wolff-Parkinson-White syndrome.
Next Document: Antigen presentation by liposomes bearing class II MHC and membrane IL-1.