Document Detail

Neural responses of OCD patients towards disorder-relevant, generally disgust-inducing and fear-inducing pictures.
MedLine Citation:
PMID:  15935263     Owner:  NLM     Status:  MEDLINE    
This functional magnetic resonance imaging study investigated the disgust- and fear-reactivity of patients suffering from obsessive-compulsive disorder (OCD). Ten OCD patients were scanned while viewing blocks of pictures showing OCD triggers from their personal environment and OCD-irrelevant disgust-inducing, fear-inducing and neutral scenes. Afterwards, the patients rated the intensity of the induced disgust, fear and OCD symptoms. The responses were compared with those of 10 healthy control subjects. The disorder-relevant pictures provoked intense OCD symptoms in the clinical group associated with increased activation in the bilateral prefrontal cortex, the left insula, the right supramarginal gyrus, the left caudate nucleus and the right thalamus. The patients gave higher disgust and fear ratings than the controls for all aversive picture categories. Neural responses towards the disorder-irrelevant disgusting and fear-inducing material included more pronounced insula activation in patients than controls. Summarizing, photos of individual OCD-triggers are an effective means of symptom provocation and activation of the fronto-striato-thalamo-parietal network. The increased insular reactivity of OCD patients during all aversive picture conditions might mirror their susceptibility to experience negative somatic states.
Anne Schienle; Axel Schäfer; Rudolf Stark; Bertram Walter; Dieter Vaitl
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2005-04-22
Journal Detail:
Title:  International journal of psychophysiology : official journal of the International Organization of Psychophysiology     Volume:  57     ISSN:  0167-8760     ISO Abbreviation:  Int J Psychophysiol     Publication Date:  2005 Jul 
Date Detail:
Created Date:  2005-06-06     Completed Date:  2005-07-27     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8406214     Medline TA:  Int J Psychophysiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  69-77     Citation Subset:  IM    
Bender Institute of Neuroimaging, University of Giessen, Germany, Department of Psychology, University of Trier, Germany.
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MeSH Terms
Anxiety / psychology
Cerebrovascular Circulation / physiology
Emotions / physiology*
Fear / physiology*
Hemodynamics / physiology
Magnetic Resonance Imaging
Middle Aged
Obsessive-Compulsive Disorder / physiopathology*,  psychology
Photic Stimulation
Psychiatric Status Rating Scales

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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